کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6286469 1615377 2015 49 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modeling
ترجمه فارسی عنوان
سلول های بنیادی تک سلولی منجر به بیماری پارکینسون: منبع سلولی جدید سلول درمانی و مدل سازی بیماری
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) are two novel cell sources for studying neurodegenerative diseases. Dopaminergic neurons derived from hiPSCs/hESCs have been implicated to be very useful in Parkinson's disease (PD) research, including cell replacement therapy, disease modeling and drug screening. Recently, great efforts have been made to improve the application of hiPSCs/hESCs in PD research. Considerable advances have been made in recent years, including advanced reprogramming strategies without the use of viruses or using fewer transcriptional factors, optimized methods for generating highly homogeneous neural progenitors with a larger proportion of mature dopaminergic neurons and better survival and integration after transplantation. Here we outline the progress that has been made in these aspects in recent years, particularly during the last year, and also discuss existing issues that need to be addressed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 134, November 2015, Pages 161-177
نویسندگان
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