کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
63627 48245 2016 9 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Pharmaceutical co-crystals of the anti-inflammatory drug diflunisal and nicotinamide obtained using supercritical CO2 as an antisolvent
ترجمه فارسی عنوان
کریستال های co دارویی diflunisal داروی ضدالتهابی و نیکوتین آمید با استفاده از CO2 فوق بحرانی به عنوان ضد حلال
کلمات کلیدی
API، ماده دارویی فعال؛ BPR، تنظیم کننده فشار عقب؛ C، غلظت محلول؛ DIF، diflunisal؛ DSC، calorimetry اسکن دیفرانسیل؛ FTIR، تبدیل فوریه مادون قرمز؛ GAS، ضد انحلال گاز؛ NIC، nicot
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
چکیده انگلیسی

A method based on using supercritical CO2 as an antisolvent (SAS method) is explored as a co-crystallization technique. Co-crystallization is an emerging and powerful technique to improve the physicochemical properties of an active pharmaceutical ingredient. The solid-state and solution co-crystallization methods usually employed present several disadvantages. The one-step SAS method has a low environmental impact and overcomes some of the difficulties associated to conventional methods. The 2:1 co-crystals of the anti-inflammatory drug diflunisal (DIF) and nicotinamide (NIC) are prepared for the first time by SAS. Drug concentrations corresponding to the co-crystal stoichiometric composition are used. The influence of the SAS parameters temperature (35 and 40 °C), pressure (10.0 and 12.0 MPa), drug concentration (two levels) and solvent (acetone and ethanol) in the co-crystal formation is studied. A crystalline material in the form of needles of uniform width and more variable length is obtained. For comparison purposes, pure DIF and NIC are also processed by SAS. Co-crystals are characterized in terms of crystallinity, thermal behavior, coformer interactions and drug release; their dissolution rate improves with respect to that of pure DIF. SAS co-crystals exhibit the same crystal structure, melting point and FTIR spectrum as those previously obtained by liquid assisted ball mill grinding and solution crystallization.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of CO2 Utilization - Volume 13, March 2016, Pages 29–37
نویسندگان
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