کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6370743 | 1623877 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A single formula to describe radiation-induced protein relocalization: Towards a mathematical definition of individual radiosensitivity
ترجمه فارسی عنوان
یک فرمول یک برای توصیف تغییر محلول پروتئین ناشی از اشعه: به یک تعریف ریاضی از حساسیت رادیویی فردی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
Immunofluorescence with antibodies against DNA damage repair and signaling protein is revolutionarising the estimation of the genotoxic risk. Indeed, a number of stress response proteins relocalize in nucleus as identifiable foci whose number, pattern and appearance/disappearance rate depend on several parameters such as the stress nature, dose, time and individual factor. Few authors proposed biomathematical tools to describe them in a unified formula that would be relevant for all the relocalizable proteins. Based on our two previous reports in this Journal (Foray et al., 2005; Gastaldo et al., 2008), we considered that foci response to stress is composed of a recognition and a repair phase, both described by an inverse power function provided from a Euler's Gamma distribution. The resulting unified formula called “Bodgi's function” is able to describe appearance/disappearance kinetics of nuclear foci after any condition of genotoxic stress. By applying the Bodgi's formula to DNA damage repair data from 45 patients treated with radiotherapy, we deduced a classification of human radiosensitivity based on objective molecular criteria, notably like the number of unrepaired DNA double-strand breaks and the radiation-induced nucleo-shuttling of the ATM kinase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 333, 21 September 2013, Pages 135-145
Journal: Journal of Theoretical Biology - Volume 333, 21 September 2013, Pages 135-145
نویسندگان
Larry Bodgi, Adeline Granzotto, Clément Devic, Guillaume Vogin, Annick Lesne, Jean-François Bottollier-Depois, Jean-Marc Victor, Mira Maalouf, Georges Fares, Nicolas Foray,