کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
6463105 1361924 2017 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Mitochondrial control region diversity in Sindhi ethnic group of Pakistan
ترجمه فارسی عنوان
تنوع منطقه کنترل میتوکندری در گروه قومی سندی پاکستان
کلمات کلیدی
mtDNA؛ منطقه کنترل؛ سندی؛ پاکستان؛
mtDNA; Control region; Sindhi; Pakistan;
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی

•Total 88 Sindhi samples from Pakistan were analyzed for entire mtDNA control region.•South Asian haplogroups were found to be predominated.•Genetic diversity of the Sindhis is of highest value after Pathans of Pakistan.•First step towards construction of quality mtDNA database for Sindh Province.

The entire mitochondrial DNA control region (nt 16024–576) of 88 unrelated individuals of Sindhi ethnic group residing in different parts of Sindh province of Pakistan was sequenced. Out of 66 different observed haplotypes 50 were unique and 16 were shared by more than one individual. Results showed admixture of mtDNA pool constituting the haplogroups derived mainly from South Asia (47.6%) and West Eurasian (35.7%) whereas the contribution of the African haplogroup was very small (2.4%). High values of genetic diversity (0.992), power of discrimination (0.981) and low value of random match probability (0.018) indicates that mtDNA analysis for this population can effectively be used for forensic casework. The results are valuable contribution towards building mtDNA population variation database for this particular ethnic group from Pakistan.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Legal Medicine - Volume 26, May 2017, Pages 11-13
نویسندگان
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