کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6481963 1608284 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurocognitive impairment is associated with corpus callosum atrophy in multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Neurocognitive impairment is associated with corpus callosum atrophy in multiple sclerosis
چکیده انگلیسی

The objective of this study was to evaluate the association between annualized corpus callosum (aCC) atrophy and cognitive impairment in multiple sclerosis (MS) patients. This is a cohort study of clinically isolated syndrome suggestive of multiple sclerosis (CIS) and relapsing-remitting multiple sclerosis (RRMS) patients based on an analysis of serial MRI examinations. The validated Multiple Sclerosis Inventory Cognition (MUSIC) was used to assess cognitive dysfunction. 39% of patients (n = 17, mean score 15.5 ± 2.9) had cognitive dysfunction and 61% (n = 27, mean score 23.6 ± 2.5) had no signs of cognitive impairment. Overall mean annualized corpus callosum index (aCCI) change was −0.72% ± 0.96%. Patients with cognitive dysfunction presented higher aCCI reduction: 0.95% ± 0.78% in comparison with patients without signs of cognitive impairment: 0.57% ± 1.06% (p = 0.044). Multivariate analysis revealed that aCC atrophy (β = 227.1; p = 0.05) was an independent predictor of cognitive impairment (adjusted R2 = 0.355; F = 1.777; p = 0.02). Progression of aCC atrophy is associated with the development of cognitive dysfunction in MS patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurology, Psychiatry and Brain Research - Volume 22, Issues 3–4, December 2016, Pages 173-177
نویسندگان
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