کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6481963 | 1608284 | 2016 | 5 صفحه PDF | دانلود رایگان |
The objective of this study was to evaluate the association between annualized corpus callosum (aCC) atrophy and cognitive impairment in multiple sclerosis (MS) patients. This is a cohort study of clinically isolated syndrome suggestive of multiple sclerosis (CIS) and relapsing-remitting multiple sclerosis (RRMS) patients based on an analysis of serial MRI examinations. The validated Multiple Sclerosis Inventory Cognition (MUSIC) was used to assess cognitive dysfunction. 39% of patients (n = 17, mean score 15.5 ± 2.9) had cognitive dysfunction and 61% (n = 27, mean score 23.6 ± 2.5) had no signs of cognitive impairment. Overall mean annualized corpus callosum index (aCCI) change was â0.72% ± 0.96%. Patients with cognitive dysfunction presented higher aCCI reduction: 0.95% ± 0.78% in comparison with patients without signs of cognitive impairment: 0.57% ± 1.06% (p = 0.044). Multivariate analysis revealed that aCC atrophy (β = 227.1; p = 0.05) was an independent predictor of cognitive impairment (adjusted R2 = 0.355; F = 1.777; p = 0.02). Progression of aCC atrophy is associated with the development of cognitive dysfunction in MS patients.
Journal: Neurology, Psychiatry and Brain Research - Volume 22, Issues 3â4, December 2016, Pages 173-177