کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6595831 | 458550 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fast and accurate parameter sensitivities for the general rate model of column liquid chromatography
ترجمه فارسی عنوان
حساسیت پارامترهای سریع و دقیق برای مدل نرخ کلی کروماتوگرافی مایع ستون
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کلمات کلیدی
MCLOpenMPGRMMPMIDAParameter sensitivitiesBDFGPLIVPMobile phase modifierWENOFinite differences - تفاضل محدودAlgorithmic Differentiation - تنوع الگوریتمیFinite volumes - حجم محدودSMA - دبیرستانDae - دلمIdas - شرقSteric mass action - عمل توده استریکBackward differentiation formula - فرمول تمایز عقب ماندهGeneral rate model - مدل نرخ کلیInitial value problem - مشکل ارزش اولیهDifferential-algebraic equation - معادله دیفرانسیل-جبریWeighted essentially non-oscillatory - وزن اساسا غیر نوسانی استColumn liquid chromatography - کروماتوگرافی مایع ستون
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
A fast and accurate solver for the general rate model is extended for computing sensitivities that describe the impact of small parameter changes on the simulated chromatograms. Parameter sensitivities are required by many optimization algorithms and are useful for understanding how chromatograms depend on specific system properties or operating conditions. They are efficiently computed with arbitrary precision by integrating a forward sensitivity DAE system that is derived from the original DAE system. The involved partial derivatives are either manually derived or computed by algorithmic differentiation. This approach is demonstrated to be more robust and faster for realistically sized problems, as compared to the traditional finite difference approach. Sensitivities are computed not only with respect to intrinsic model parameters, such as diffusion coefficients and isotherm parameters, but also with respect to parameters in the boundary concentrations, such as the slope of an elution salt gradient. The extended solver is part of the Chromatography Analysis and Design Toolkit (CADET).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 56, 13 September 2013, Pages 46-57
Journal: Computers & Chemical Engineering - Volume 56, 13 September 2013, Pages 46-57
نویسندگان
Andreas Püttmann, Sebastian Schnittert, Uwe Naumann, Eric von Lieres,