کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6817741 | 1433954 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Depression and fatigue in multiple sclerosis: Relation to exposure to violence and cerebrospinal fluid immunomarkers
ترجمه فارسی عنوان
افسردگی و خستگی در مولتیپل اسکلروزیس: ارتباط نزدیکی با خشونت و ایمنوگلوبین های مایع مغزی نخاعی
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کلمات کلیدی
مولتیپل اسکلروزیس، اینترلوکین، افسردگی، خستگی، فشار، معلولیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Multiple sclerosis (MS) is a neuroinflammatory condition characterized by chronic dysregulation of immune responses leading to repeated episodes of inflammation in the central nervous system. Depression and fatigue are common among MS patients, even in early disease phases, and the disease course can be negatively affected by stressful events. IL-6 and IL-8 have been associated with depression and stressful life events in non-MS patients. The aim of this study was to examine the relationships between depression, fatigue, and exposure to violence, with IL-6 and IL-8 levels in the cerebrospinal fluid (CSF) of MS patients. Levels of IL-6 and -8 were analyzed in the CSF of 47 patients with relapsing-remitting MS. Correlations between IL-6 and IL-8 levels and self-rated depression and fatigue symptoms, as well as clinician-rated history of being exposed to interpersonal violence, were analyzed with correction for age, sex and MS disability status. IL-6 correlated significantly (pâ¯<â¯0.05) with depressive symptoms (adjusted Spearman's Ïâ¯=â¯0.39), fatigue (Ïâ¯=â¯0.39), and exposure to violence in adult life (Ïâ¯=â¯0.35). Depression correlated with both fatigue and being exposed to violence. Associations were not present among patients exposed to disease modifying drugs. In exploratory analyses, the relationship between exposure to violence and IL-6 was non-significant when controlled for depression. Further research should focus on replication of these results, as well as exploring the impact of stressful life events on immune regulation and the clinical characteristics and prognosis of MS patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 89, March 2018, Pages 53-58
Journal: Psychoneuroendocrinology - Volume 89, March 2018, Pages 53-58
نویسندگان
Philip Brenner, Mathias Granqvist, Johan Königsson, Faiez Al Nimer, Fredrik Piehl, Jussi Jokinen,