کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6898905 1446423 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Patulin interference with ATP binding cassette transferring auto inducer −2 in Salmonella typhi and biofilm inhibition via quorum sensing
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
Patulin interference with ATP binding cassette transferring auto inducer −2 in Salmonella typhi and biofilm inhibition via quorum sensing
چکیده انگلیسی
Salmonella typhi are Gram-negative pathogens that infect many hosts including humans and animals and cause diseases ranging from gastroenteritis and diarrhea to life-threatening systemic syndrome. Owing to the metabolic versatility, they will colonize as multi cellular aggregates on various surfaces to enhance the virulence by forming a biofilm in which bacterial cells are more resistant to antibiotics than planktonic cells. Quorum Sensing (QS) is a cell-to-cell communication mechanism in the bacterial system to coordinate group behaviors such as biofilms formation and virulence factors production. In QS system ATP Binding Cassette (ABC) transporter component, LsrA, plays a key role to transport autoinducer-2 (AI-2) to increase the cell density. In order to reduce biofilm formation, patulin was selected as a natural QS inhibitor and its function was studied by biofilm inhibitory assays. Significant differences in the spectroscopic values were obtained between antibiotic resistance of kanamycin (30 μg/ml) and patulin (30 μg/ml). Furthermore, to distinguish the molecular level interaction of LsrA, patulin and AI-2 were docked. Both the compounds were interact in the same pose with Glide score of −4.237 kcal/mol and −7.126 kcal/mol respectively. These results will suggest that patulin is the efficient Quorum Sensing Inhibitor to control biofilm formation in S.typhi.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Informatics in Medicine Unlocked - Volume 11, 2018, Pages 9-14
نویسندگان
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