کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7239569 1471281 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
El agonista del receptor de serotonina-2C Ro 60-0175 decrementa la expresión de la sensibilización locomotora inducida por etanol
موضوعات مرتبط
علوم انسانی و اجتماعی روانشناسی روان شناسی کاربردی
پیش نمایش صفحه اول مقاله
El agonista del receptor de serotonina-2C Ro 60-0175 decrementa la expresión de la sensibilización locomotora inducida por etanol
چکیده انگلیسی
The main goal of the present research was to evaluate the effects of 5-HT2C receptor agonist Ro 60-0175 on the expression of ethanol-induced locomotor sensitization. In order to determine if these effects result from a specific action of Ro 60-0175 on 5-HT2C receptors, we also examined the effects of the selective 5-HT2C receptor antagonist SB 242084 on Ro 60-0175's effects on the ethanol-induced locomotor sensitization. Different groups of rats were subjected to development of ethanol-induced locomotor sensitization. On the expression tests of the locomotor sensitization the effects of the Ro 60-0175 and SB 242084 on the ethanol-induced locomotor sensitization were evaluated. In addition, the pretreatment with SB 242084 on the effects of Ro 60-0175 on the ethanol-induced locomotor sensitization was also evaluated. The results showed that Ro 60-0175 produced a dose-dependent prevention of the expression of ethanol-induced locomotor sensitization. This effect was reversed by administration of SB 242084. These data suggest that 5-HT2C receptors play a regulatory role on ethanol-induced locomotor sensitization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta de Investigación Psicológica - Volume 7, Issue 3, December 2017, Pages 2823-2831
نویسندگان
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