کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7688941 1645383 2016 55 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments
ترجمه فارسی عنوان
روش های تحلیلی برای کنترل کیفیت داروها از لحاظ محتوای حلال های باقی مانده: چالش ها و تحولات اخیر
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Residual solvents play an important role in the synthesis of drugs and in product formulations. In addition, they pose a serious problem, that is toxicity, as many of them exhibit toxic or environmentally hazardous properties. Therefore, constant monitoring of quality control is needed. In this study, we present an overview of regulatory and general methods described by various pharmacopoeias. Then, the most commonly used methodologies for the determination of residual solvents in different pharmaceutical samples are reviewed to demonstrate their limitations, which form the basis of discussion about new methods. Several interesting new alternatives for sample preparation and gas chromatography (GC) separation are presented using examples from recent studies. The techniques described are direct injection, headspace analysis with different modifications and variations, liquid extraction, single-drop microextraction, and solid-phase microextraction. Various GC separation techniques are compared and new solutions to improve sensitivity and efficiency are presented.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 80, June 2016, Pages 328-344
نویسندگان
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