کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7698460 | 1496566 | 2017 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A facile synthesis of novel indole derivatives as potential antitubercular agents
ترجمه فارسی عنوان
سنتز مؤثر مشتقات رمانندول به عنوان عوامل بالقوه ضد توبولار
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
چکیده انگلیسی
A novel series of 5,5-dimethyl-11-phenyl-4b,5,5a,10,10a,11,11a,12-octahydro-10,11,12-triaza-indeno[2,1-b]fluorenes 3a-3l were prepared by reacting oxindole, aryl amines and acetone using dibutylamine as an organocatalyst via simultaneous Knoevenagel and Michael-type reactions. This preparation is environmentally benign, highly compatible and conveniently carried out in ethanol under mild conditions. The structures of the new compounds were determined by spectroscopic techniques, including IR, 1H NMR, 13C NMR and LCHRMS. Docking studies against an enoyl acyl carrier protein reductase predicted that the compounds possessed high binding affinity towards target molecules. The compound 3k (MIC, 40 μg/mL) showed comparable activity with Isoniazid at the same concentrations against MT H37 Rv.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Taibah University for Science - Volume 11, Issue 6, November 2017, Pages 910-921
Journal: Journal of Taibah University for Science - Volume 11, Issue 6, November 2017, Pages 910-921
نویسندگان
Gulzar A. Khan, Javeed A. War, Arun Kumar, Imtiyaz A. Sheikh, Aarti Saxena, Ratnesh Das,