Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 24, Issue 21, 1 November 2016, Pages 5340-5352

Akane Kamiyama, Mado Nakajima, Liyou Han, Kei Wada, Masaharu Mizutani, Yukiko Tabuchi, Akiko Kojima-Yuasa, Isao Matsui-Yuasa, Hideyuki Suzuki, Keiichi Fukuyama, Bunta Watanabe, Jun Hiratake,