کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7782811 1500567 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein adsorption onto polysaccharides: Comparison of chitosan and chitin polymers
ترجمه فارسی عنوان
جذب پروتئین بر روی پلی ساکارید ها: مقایسه پلیمرهای کیتوزان و کیتین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Chitosan (CHS) and chitin (CHT) biopolymers have found many applications in the field of controlled-release drug delivery systems. Herein, molecular dynamics (MD) simulation and binding free energy calculations were used to investigate the potentials of CHS and CHT polymers for the controlled release of follicle-stimulating hormone (FSH). The results indicated that FSH conformation did not change in the presence of CHS and CHT. In addition, FSH-polymer interactions caused stability of the 310-helix structure of the alpha subunits of FSH (FSHα). Both the biopolymers interacted with the protein mainly through the hydrophobic forces. CHS has more affinity for FSH when compared with CHT. Furthermore, in both systems, the affinity of polymers for FSHα was more than that for beta subunits of FSH (FSHβ). The results suggested that the polysaccharides might improve the controlled-release FSH delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 191, 1 July 2018, Pages 191-197
نویسندگان
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