کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7888638 1509796 2018 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fabrication and preliminary biological evaluation of a highly porous biphasic calcium phosphate scaffold with nano-hydroxyapatite surface coating
ترجمه فارسی عنوان
ساخت و ارزیابی بیولوژیکی یک داربست کلسیم فسفات دو طرفه بسیار متخلخل با پوشش سطح نانو هیدروکسی آپاتیت
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سرامیک و کامپوزیت
چکیده انگلیسی
Considering that the structure of scaffold determines its functionality, in this study biphasic calcium phosphate (BCP) scaffold with highly interconnected macroporous structure was firstly fabricated by a polymeric sponge replication method, in which a ethanol solution (25 vol%) was use for preparation of the slurry and a varying slurry viscosity during multiple impregnations was adopted. Then, the surface coating consisting of nano-hydroxyapatite (nHA) particles was formed by a dip coating technology, i.e. immersing the porous scaffold into the nHA slurry (20 mg/mL) and sintering it at 650 °C. Preliminary in vitro experiments showed that compared to BCP one, nHA-coated BCP scaffold could increase protein adsorption, form more complex bone-like apatite, and promote cell adhesion and proliferation, indicating that nHA-coated BCP scaffold exhibited superior biocompatibility and bioactivity. It might be attributed to its surface nanostructure and abundant nano- to micro- scale pores (< 10 µm). This nHA-coated BCP scaffold with both trabecular framework and surface nanoscale topography holds great promise in serving as bone graft for the orthopedic application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ceramics International - Volume 44, Issue 2, 1 February 2018, Pages 1304-1311
نویسندگان
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