کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8248176 1533325 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A modified formula for dose calculations of stereotactic ablative body radiotherapy for non-small cell lung cancer
ترجمه فارسی عنوان
یک فرمول اصلاح شده برای محاسبه دوز از رادیوتراپی بدن ستون فقراتی برای سلول های ریه غیر سلولی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
چکیده انگلیسی
To provide a modified formula consistent with the Monte Carlo (MC) algorithm for dose calculations during stereotactic ablative body radiotherapy for non-small cell lung cancer. Seventy CyberKnife treatment plans were calculated and analyzed by MC and ray-tracing (RT) algorithms, separately. Parameters of treatment plans were compared, and those associated with differences of dose distributions were analyzed to establish a modified formula. Gross tumor volume and tumor tracking volume (TTV) were defined as the evident disease on the sequences of the window width and level of the lung and the mediastinum. Additionally, the formula was validated by another 20 plans. The prescription dose of the 90 patients was 60 Gy/5f. The RT algorithm overestimated the planning target volume (PTV) D95 by an average of 8.59 Gy and the gross tumor volume D99 by an average of 5.84 Gy. The homogeneity index of PTV was underestimated by 0.11 on average, whereas the conformity index and new conformity index was underestimated by 0.05. The RT algorithm overestimated the dose distribution to the spinal cord by 2.23 Gy, the esophagus by 1.96 Gy, the trachea by 1.89 Gy, the left-sided bronchus by 1.77 Gy, the right-sided bronchus by 1.64 Gy, and the heart by 2.16 Gy. The average whole-lung dose volumes of lung tissues and dose volumes of V5 were overestimated by 2.69 Gy and 7.52%, respectively. A power function distribution (R2 = 0.8626) was confirmed between PTV D95 and TTV volumes. PTV D95 calculated by the MC algorithm could be computed easily with TTV and PTV D95 calculated by the RT algorithm based on the formula. The modified equation was more consistent with MC algorithm than with other formula, which could be a reference to those not accessible to the MC algorithm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Dosimetry - Volume 43, Issue 3, Autumn 2018, Pages 207-213
نویسندگان
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