کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8309743 | 1538622 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical significance of GalNAcylated glycans in cholangiocarcinoma: Values for diagnosis and prognosis
ترجمه فارسی عنوان
اهمیت بالینی گلیسانی گالاسیونالیته در کلانژیوکارسینوم: ارزش تشخیص و پیش آگهی
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کلمات کلیدی
Sophora japonica agglutininGalNAc-transferaseGalNAc-transferases(BSA)N-nitrosodimethylamine - N-نیترزودیمتییلامینbovine serum albumin - آلبومین سرم گاوcarbohydrate antigen - آنتی ژن کربوهیدراتBiomarker - بیومارکرtetramethylbenzidine - تترامتیل بنزیدینBile duct cancer - سرطان مجرای صفراویLectin - لکتینMucin - موسین Arbitrary Unit - واحد خودآموزCholangiocarcinoma - کلانژیوکارسینومایhealthy controls - کنترل های سالمGlycosylation - گلیکوزیله شدنreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Cancer cells exhibited the aberrant cancer-associated glycans that are potential biomarkers for diagnosis and monitoring of the cancer. In this study, Sophora japonica agglutinin (SJA) was used to detect SJA-specific N-acetylgalactosamine-associated glycans (SNAG) in liver tissues and sera from cholangiocarcinoma (CCA) patients. Whether SNAG could be the diagnostic and prognostic markers for CCA was evaluated. SJA-histochemistry revealed that SNAG was undetec2 in normal bile ducts but was highly expressed in hyperplastic/dysplastic bile ducts and CCA. SNAG was negative in hepatocytes and hepatoma tissues indicating SNAG as a differential marker of CCA and hepatoma. SJA-histochemistry of CCA hamster tissues revealed the involvement of SNAG in the early pathogenesis of bile duct epithelia and CCA development. A SJA-based ELISA was successfully developed to determine SNAG in serum. Serum-SNAG from CCA patients was significantly higher than those of non-CCA control groups with the diagnostic values of 59.5% sensitivity and 73.6% specificity, comparable to those of serum CA19-9. High levels of serum SNAG (â¥Â 69 AU/ml) indicated poor survival of CCA patients. Taken together, SNAG was first demonstrated here to be a glycobiomarker for diagnosis and prognosis of CCA. Association of SNAG with pathogenesis of bile ducts and CCA development were suggested. (198).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 477, February 2018, Pages 66-71
Journal: Clinica Chimica Acta - Volume 477, February 2018, Pages 66-71
نویسندگان
Waraporn Saentaweesuk, Atit Silsirivanit, Kulthida Vaeteewoottacharn, Kanlayanee Sawanyawisuth, Chawalit Pairojkul, Ubon Cha'on, Somsiri Indramanee, Somchai Pinlaor, Thidarut Boonmars, Norie Araki, Chaisiri Wongkham,