کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8384020 1543461 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EZH2 phosphorylation regulates Tat-induced HIV-1 transactivation via ROS/Akt signaling pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
EZH2 phosphorylation regulates Tat-induced HIV-1 transactivation via ROS/Akt signaling pathway
چکیده انگلیسی
EZH2 plays a major role in HIV-1 latency, however, the molecular linkage between Tat-induced HIV-1 transactivation and EZH2 activity is not fully understood. It was shown Tat induced HIV-1 transactivation through inhibiting EZH2 activity. Tat decreased the levels of H3K27me3 and EZH2 occupy at the long terminal repeat (LTR) of HIV-1. We further showed for the first time that transfected with Tat construct resulted in an increase in phosphorylated EZH2 (p-EZH2), mediated by active Akt. ROS/Akt-dependent p-EZH2 was correlated with Tat-induced transactivation. Our study reveals that novel mechanisms allow Tat-induced HIV-1 transactivation by ROS/Akt-dependent downregulating the EZH2 epigenetic silencing machinery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 24, Part B, 21 December 2015, Pages 4106-4111
نویسندگان
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