کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8479986 1551352 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanosensing in hypothalamic osmosensory neurons
ترجمه فارسی عنوان
مکانیسم زایی در نورونهای هیپوتالاموس اسمزنسورس
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
Osmosensory neurons are specialized cells activated by increases in blood osmolality to trigger thirst, secretion of the antidiuretic hormone vasopressin, and elevated sympathetic tone during dehydration. In addition to multiple extrinsic factors modulating their activity, osmosensory neurons are intrinsically osmosensitive, as they are activated by increased osmolality in the absence of neighboring cells or synaptic contacts. This intrinsic osmosensitivity is a mechanical process associated with osmolality-induced changes in cell volume. This review summarises recent findings revealing molecular mechanisms underlying the mechanical activation of osmosensory neurons and highlighting important roles of microtubules, actin, and mechanosensitive ion channels in this process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 71, November 2017, Pages 13-21
نویسندگان
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