Immune responses to bacterial and fungal infections in the silkworm, Bombyx mori

The silkworm Bombyx mori, an economically important insect that is usually reared indoors, is susceptible to various pathogens, including bacteria, fungi, viruses, and microsporidia. As with other insects, the silkworm lacks an adaptive immune system and relies solely on innate immunity to defend itself against infection. Compared to other intensively studied insects, such as the fruit fly and tobacco hornworm, the principal immune pathways in the silkworm remain unclear. In this article, we review the literature concerning silkworm immune responses to bacteria and fungi and present our perspectives on future research into silkworm immunity.