کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8513178 | 1556490 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spectral Reflectance Measurement of Evaporating Chemical Films: Initial Results and Application to Skin Permeation
ترجمه فارسی عنوان
اندازه گیری انعکاس طیفی فیلم های شیمیایی تبخیر: نتایج اولیه و کاربرد آن در نفوذ پوست
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The present study has 2 aims. First, the method of spectral reflectance was used to measure evaporation rates of thin (â¼25-300 μm) films of neat liquid volatile organic chemicals exposed to a well-regulated wind speed u. Gas-phase evaporation mass transfer coefficient (kevap) measurements of 10 chemicals, 9 of which were measured at similar u, are predicted (slope of log-log data = 1.01; intercept = 0.08; R2 = 0.996) by a previously proposed mass transfer correlation. For one chemical, isoamyl alcohol, the dependence of kevap on u0.52 was measured, in support of the predicted exponent value of ½. Second, measured kevap of nicotine was used as an input in analytical models based on diffusion theory to estimate the absorbed fraction (Fabs) of a small dose (5 μL/cm2) applied to human epidermis in vitro. The measured Fabs was 0.062 ± 0.023. Model-estimated values are 0.066 and 0.115. Spectral reflectance is a precise method of measuring kevap of liquid chemicals, and the data are well described by a simple gas-phase mass transfer coefficient. For nicotine under the single exposure condition measured herein, Fabs is well-predicted from a theoretical model that requires knowledge of kevap, maximal dermal flux, and membrane lag time.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 8, August 2018, Pages 2251-2258
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 8, August 2018, Pages 2251-2258
نویسندگان
H. Frederick Frasch, Larry Lee, Ana M. Barbero,