کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8525343 | 1557940 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effects of phycocyanin on ischemia/reperfusion liver injuries
ترجمه فارسی عنوان
اثر محافظتی فایکوسیانین بر آسیب های کبدی ایسکمی / رپرفیوژن
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کلمات کلیدی
DTNBMDASpirulina platensisTNBCDNBALTTBARSTBSGPXPhycocyaninGSTGSH1-chloro-2,4-dinitrobenzene - 1-کلرو-2،4-دینیتروبنزنIRI - IRROS - ROSAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Ischemia/reperfusion injury - آسیب شناسی ایسکمی / رپرفیوژنAlanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییischemia/reperfusion - ایسکمی / رپرفیوژنcold ischemia - ایسکمی سردTris-buffered saline - تریس بافر شورOxidative stress - تنش اکسیداتیوmalondialdehyde - مالون دی آلدهیدRat - موش صحراییglutathione-S-transferase - گلوتاتیون S-ترانسفرازglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
In this study, phycocyanin (Pc) extracted from Spirulina platensis was used to evaluate its antioxidants effects after ischemia/reperfusion injury (IRI) using the ex-vivo model of isolated perfused rat liver. The rats were divided into eight groups : Control group, where livers were directly perfused after their removal; Cold Ischemia group (CI), livers were treated in the same way as the control group, except that after their collection, they were stored for 12â¯h and 24â¯h in the Krebs Henseleit (KH) preservation solution at 4â¯Â°C and Treated group (PHY), livers were preserved in the same way as the preceding group except that the KH solution was enriched with phycocyanin at two different concentrations. Pc, a powerful antioxidant, significantly reduced ischemia/reperfusion injury in the liver. In fact, the addition of phycocyanin to the preservation solution significantly decreased the activity of liver transaminases (AST) and (ALT), alkaline phosphatase (ALP), the rate of lipid peroxidation (MDA) and the activity of certain antioxidant enzymes, essentially glutathione-S-transferase (GST) and glutathione peroxidase (GPx). On the other hand, Pc increases the level of thiol groups in hepatic tissues. In conclusion, the results show the Pc-enriched KH conservation solution is effective in preserving the hepatic graft and protecting it against IRI by acting as a potent antioxidant against the products of oxidative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 102, June 2018, Pages 196-202
Journal: Biomedicine & Pharmacotherapy - Volume 102, June 2018, Pages 196-202
نویسندگان
Neyla Ben Gdara, Amel Belgacem, Ikram Khemiri, Safa Mannai, Lotfi Bitri,