کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8525759 1557944 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genomic stability and telomere regulation in skeletal muscle tissue
ترجمه فارسی عنوان
پایداری ژنومی و تنظیم تلومر در بافت ماهیچه اسکلتی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی
Muscle injuries are common, especially in sports and cumulative trauma disorder, and their repair is influenced by free radical formation, which causes damages in lipids, proteins and DNA. Oxidative DNA damages are repaired by base excision repair and nucleotide excision repair, ensuring telomeric and genomic stability. There are few studies on this topic in skeletal muscle cells. This review focuses on base excision repair and nucleotide excision repair, telomere regulation and how telomeric stabilization influences healthy muscle, injured muscle, exercise, and its relationship with aging. In skeletal muscle, genomic stabilization and telomere regulation seem to play an important role in tissue health, influencing muscle injury repair. Thus, therapies targeting mechanisms of DNA repair and telomeric regulation could be new approaches for improving repair and prevention of skeletal muscle injuries in young and old people.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 98, February 2018, Pages 907-915
نویسندگان
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