کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8538797 | 1561120 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Atorvastatin and insulin equally mitigate brain pathology in diabetic rats
ترجمه فارسی عنوان
آتورواستاتین و انسولین به طور یکسان آسیب مغزی را در موش های دیابتی کاهش می دهند
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کلمات کلیدی
STZDCFHDADMISMDAT1DMT2DMHMG-CoAECLDMSBCATBADMITCAAβ3-hydroxy-3-methylglutaryl coenzyme A - 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم AROS - ROSAtorvastatin - آتورواستاتینbicinchoninic acid assay - آزمون اسید بیستینکونینیکstreptozotocin - استرپتوزوتوسینtrichloroacetic acid - اسید ترشکلراکتیکinsulin - انسولینamyloid beta - بتا آمیلوئیدenhanced chemiluminescence - بهبود شیمیایی لومنDiabetes mellitus type 1 - دیابت نوع 1Diabetes mellitus type 2 - دیابت نوع 2malondialdehyde - مالون دی آلدهیدDiabetic rats - موش های دیابتیcontrol rats - موش های کنترلhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Although insulin and atorvastatin have been shown to exert glycemic control and could improve brain function, the effects of atorvastatin or insulin as well as the combination of atorvastatin plus insulin on brain pathology in diabetes mellitus type 1 (T1DM) are unclear. Therefore, this study investigated the effect of atorvastatin, insulin or combined drugs on brain pathology in streptozotocin-induced diabetic rats. Thirty-six male rats were divided into two groups, a control group (nâ¯=â¯12) and a diabetic or experimental group (nâ¯=â¯24). Diabetic rats were further divided into four groups (nâ¯=â¯6/group) and the groups received either a vehicle (normal saline), atorvastatin (10â¯mg/kg/day), insulin (4â¯U/day) or a combination of the drugs for 4â¯weeks. The control group rats were divided into two groups (nâ¯=â¯6/group) to receive either just the vehicle or atorvastatin for 4â¯weeks. We found that streptozotocin-induced diabetic rats developed hyperglycemia, showing evidence of increased brain oxidative stress, impaired brain mitochondrial function, increased brain apoptosis, increased tau protein expression, increased phosphorylation of tau protein expression and amyloid beta levels, and decreased dendritic spine density. Although atorvastatin and insulin therapies led to an equal reduction in plasma glucose level in these diabetic rats, the combined drug therapy showed the greatest efficacy in decreasing plasma glucose level. Interestingly, atorvastatin, insulin and the combined drugs equally mitigated brain pathology. Our findings indicate that the combined drug therapy showed the greatest efficacy in improving metabolic parameters. However, atorvastatin, insulin and the combined drug therapy shared a similar efficacy in preventing brain damage in T1DM rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 342, 1 March 2018, Pages 79-85
Journal: Toxicology and Applied Pharmacology - Volume 342, 1 March 2018, Pages 79-85
نویسندگان
Wasana Pratchayasakul, La-ongdao Thongnak, Kenneth Chattipakorn, Anusorn Lungaphin, Anchalee Pongchaidecha, Pattarapong Satjaritanun, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn C. Chattipakorn,