کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550144 | 1562027 | 2018 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Does nicotine impact tramadol abuse? Insights from neurochemical and neurobehavioral changes in mice
ترجمه فارسی عنوان
آیا مصرف نیکوتین باعث تروما می شود؟ بینش از تغییرات مغز و اعصاب و روان در موش
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
OFTNMDAN-methyl-d-aspartatebutyrylcholinesteraseBuChERNSiNOSnNOSVTANOSTBARSMWMLLEGSHNPSHNFκB - NFKBROS - ROSOpen field test - آزمایش میدان بازAChE - آهیliquid liquid extraction - استخراج مایع مایعAcetylcholinesterase - استیل کولین استرازGamma aminobutyric acid - اسید گاما آمینو بوتیریکAnxiety - اضطرابTramadol - ترامادولSocial interaction - تعامل اجتماعیtumor necrosis factor alpha - تومور نکروز عامل آلفاtyrosine hydroxylase - تیروزین هیدروکسیلازMemory - حافظهDopamine - دوپامینinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییneuronal nitric oxide synthase - سنتاز اکسید نیتریک عصبیTNF-α - فاکتور نکروز توموری آلفاnuclear factor kappa B - فاکتور هسته ای کاپا BMorris water maze - ماز آب آب موریسthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکventral tegmental area - ناحیه تگمنتوم شکمیNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازNicotine - نیکوتین Dependence - وابستگیreduced glutathione - کاهش گلوتاتیونGABA - گاباGlu - گلوglutamate - گلوتاماتReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Nicotine and tramadol concomitant drug dependence pose increasing social, economic as well as public threats. Accordingly, the present study investigated neurochemical, neurobehavioral and neuropathological changes in the brain subsequent to the interaction of nicotine and tramadol. To this end, tramadol (20â¯mg/kg, i.p) and nicotine (0.25â¯mg/kg, i.p) were administrated to male albino mice once daily for 30 days. Consequent to microglial activation, nicotine exacerbated oxidative/nitrosative stress induced by tramadol as manifest by the step-up in thiobarbituric acid reactive substances and nitric oxide subsequent to the enhanced levels of neuronal and inducible nitric oxide synthases; paralleled by decreased non-protein sulfhydryls. Increased oxidative stress by tramadol and/or nicotine sequentially augmented nuclear factor kappa B and the proinflammatory cytokine tumor necrosis factor α with the induction of apoptosis evident by the increased caspase-3 immunoreactivity. However, paradoxical to the boosted inflammation and apoptosis, heightened DA levels in the cortex parallel along with increased tyrosine hydroxylase in midbrain were apparent. Concomitant administration of tramadol and nicotine impaired spatial navigation in the Morris Water Maze test coupled with enhanced levels of acetyl- and butyryl cholinestrases. However, tramadol in association with nicotine improved social interaction while decreasing anxiety and aggression linked to chronic administration of nicotine, effects manifested by increased levels of serotonin and GABA. These results provide evidence that co-administration of tramadol and nicotine may enhance reward and dependence while reducing anxiety and aggression linked to nicotine administration. However, such combination exacerbated neurotoxic effects and elicited negative effects regarding learning and memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 67, July 2018, Pages 245-258
Journal: NeuroToxicology - Volume 67, July 2018, Pages 245-258
نویسندگان
Shimaa M. Azmy, Mai A. Abd El fattah, Sahar S. Abd El-Rahman, Somia A. Nada, Omar M.E. Abdel Salam, Mohammed F. El-Yamany, Noha N. Nassar,