Unveiling a rhythmic regulatory mode hidden in developmental tissue growth by fluorescence live imaging-based mathematical modeling

The scope of this review is to describe the experimental and theoretical evidence for cell cycle progression as a stochastic molecular and cellular process. In addition, we elucidate the rhythmic mode of tissue development that endows “biological robustness” for reproducible tissue development. Finally, we discuss the potential of the live imaging-based mathematical approach for understanding pathophysiological development in tissues.