کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8631052 | 1568847 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Crustacean cardioactive peptides: Expression, localization, structure, and a possible involvement in regulation of egg-laying in the cuttlefish Sepia officinalis
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کلمات کلیدی
small cardioactive peptideMnGSepia officinalisFPKMTFADTTACNSCPnuclear magnetic resonance - رزونانس مغناطیسی هستهایCHCA - آنها می خواهندAcetonitrile - استونیتریلTrifluoroacetic acid - اسید TrifluoroaceticELH - الهEgg-laying - تخمEgg-laying hormone - تخم مرغ تخمگذار هورمونNMR - تشدید مغناطیسی هستهای CNS - دستگاه عصبی مرکزیdithiothreitol - دیتیوتریتولCephalopod - سفالوسکوپیcentral nervous system - سیستم عصبی مرکزیFragments Per Kilobase of exon per Million fragments mapped - قطعه در هر کیلوباسیون از اگزون در هر میلیون قطعه نقشه برداری شده استOptic lobe - لوب نوریNeuropeptides - نوروپپتیدها
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study is focused on crustacean cardioactive peptides (CCAPs), a highly expressed neuropeptide family strongly suspected of being involved in the control of egg-laying. We investigated the functional and structural characterization and tissue mapping of CCAPs, as well as the expression patterns of their receptors. CCAPs appeared to be involved in oocyte transport through the oviduct and in mechanical secretion of capsular products. Immunocytochemistry revealed that the neuropeptides were localized throughout the central nervous system (CNS) and in the nerve endings of the glands involved in egg-capsule synthesis and secretion, i.e. the oviduct gland and the main nidamental glands. The CCAP receptor was expressed in these glands and in the subesophageal mass of the CNS. Multiple sequence alignments revealed a high level of conservation of CCAP protein precursors in Sepia officinalis and Loligo pealei, two cephalopod decapods. Primary sequences of CCAPs from the two species were fully conserved, and cryptic peptides detected in the nerve endings were also partially conserved, suggesting biological activity that remains unknown for the time being.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 260, 1 May 2018, Pages 67-79
Journal: General and Comparative Endocrinology - Volume 260, 1 May 2018, Pages 67-79
نویسندگان
Maxime Endress, Céline Zatylny-Gaudin, Erwan Corre, Gildas Le Corguillé, Louis Benoist, Jérôme Leprince, Benjamin Lefranc, Benoît Bernay, Alexandre Leduc, Jimmy Rangama, Anne-Gaëlle Lafont, Arnaud Bondon, Joël Henry,