کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8632860 1569024 2018 40 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies
ترجمه فارسی عنوان
نقش دوپامین مرکزی و سروتونین در چاقی انسان: درسهایی که از مطالعات تصویر برداری مولکولی یاد می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Obesity results from an imbalance between energy intake and expenditure, and many studies have aimed to determine why obese individuals continue to (over)consume food under conditions of caloric excess. The two major “neurotransmitter hypotheses” of obesity state that increased food intake is partially driven by decreased dopamine-mediated reward and decreased serotonin-mediated homeostatic feedback in response to food intake. Using molecular neuroimaging studies to visualize and quantify aspects of the central dopamine and serotonin systems in vivo, recent PET and SPECT studies have also implicated alterations in these systems in human obesity. The interpretation of these data, however, is more complex than it may appear. Here, we discuss important characteristics and limitations of current radiotracer methods and use this framework to comprehensively review the available human data on central dopamine and serotonin in obesity. On the basis of the available evidence, we conclude that obesity is associated with decreased central dopaminergic and serotonergic signaling and that future research, especially in long-term follow-up and interventional settings, is needed to advance our understanding of the neuronal pathophysiology of obesity in humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 85, August 2018, Pages 325-339
نویسندگان
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