کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8633933 | 1569087 | 2018 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Borage oil restores acidic skin pH by up-regulating the activity or expression of filaggrin and enzymes involved in epidermal lactate, free fatty acid, and acidic free amino acid metabolism in essential fatty acid-deficient Guinea pigs
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کلمات کلیدی
FFAEFADsPLA2FAAGLAEFAHCOGCaseskin pHβ-glucocerebrosidase - β-گلوکوکربروزیدازγ-linolenic acid - γ-لینولنیک اسیدFree amino acid - آمینو اسید رایگانStearic acid - اسید استئاریک Oleic acid - اسید اولئیکLinoleic acid - اسید لینولئیکFree fatty acid - اسید چرب آزادEssential fatty acid - اسید چرب ضروریFree fatty acids - اسیدهای چرب آِزادGuinea pig - خوک گینه، خوکچه هندیhydrogenated coconut oil - روغن نارگیل هیدروژنهborage oil - روغن گل گاوزبانSecreted phospholipase A2 - فسفولیپاز A2 تثبیت شدهLactate - لاکتاتlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Palmitic acid - پالمیتیک اسیدEssential fatty acid deficiency - کمبود اسید چرب ضروری
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Borage oil (BO) reverses a disrupted epidermal lipid barrier and hyperproliferation in essential fatty acid deficiency (EFAD). However, little is known about its effect on skin pH, which is maintained by epidermal lactate, free fatty acids (FFAs), and free amino acids (FAAs) which is generated by lactate dehydrogenase (LDH), secreted phospholipase A2 (sPLA2), or filaggrin degradation with peptidylarginine deiminase-3 (PADI3). We hypothesized that BO restores skin pH by regulating epidermal lactate, FFA metabolism, or FAA metabolism in EFAD. To test this hypothesis, EFAD was induced in guinea pigs by a hydrogenated coconut oil (HCO) diet for 8 weeks, followed by 2 weeks of a BO diet (group HCO + BO). As controls, groups HCO and BO were fed HCO or BO diets for 10 weeks. In group HCO + BO, skin pH, which was less acidic in group HCO, was restored; and epidermal lactate and total FFAs, including palmitate, stearate, linoleate, arachidate, behenate, and lignocerate, were higher than in group HCO. LDH and sPLA2 (mainly the PLA2G2F isoform) activities and protein expressions were similar between groups HCO + BO and BO. Epidermal acidic FAAs, as well as filaggrin and PADI3 protein and mRNA expressions were higher in group HCO + BO than in group HCO. Oleate, total FAAs including other FAAs, and LDH and sPLA2 mRNA expressions were not altered between groups HCO and HCO + BO. Basic FAAs were not altered among groups. Dietary BO restored acidic skin pH and increased epidermal levels of lactate, most FFAs, and acidic FAAs by up-regulating LDH, sPLA2, filaggrin, and PADI3 activities as well as protein or mRNA expressions in EFAD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 58, October 2018, Pages 26-35
Journal: Nutrition Research - Volume 58, October 2018, Pages 26-35
نویسندگان
Kun-Pyo Kim, Sanghun Jeon, Mi-Ju Kim, Yunhi Cho,