کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645177 | 1569777 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of vitamin D receptor gene polymorphisms with serum 25(OH)D levels and metabolic syndrome in Thai population
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کلمات کلیدی
FBGHRTDBPLDL-CHDL-C1α,25-dihydroxyvitamin D3 - 1α، 25-دی هیدروکسوییتامین D325(OH)D - 25 (OH) D25-hydroxyvitamin D - 25 هیدروکسی ویتامین DAdenine - آدنینNational Cholesterol Education Program Adult Treatment Panel III - برنامه آموزش کلسترول ملی بالغ درمان بزرگسالانcardiovascular disease - بیماری قلب و عروقیCVD - رسوب دهی شیمیایی بخار Metabolic syndrome - سندرم متابولیکcytosine - سیتوزینbody mass index - شاخص توده بدنBMI - شاخص توده بدنیdiastolic blood pressure - فشار خون دیاستولیکfasting blood glucose - قند خون ناشتاhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالMETS - متسodds ratio - نسبت شانس هاhormone replacement therapy - هورمون جایگزین درمانLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کمGuanine - گوانین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Metabolic syndrome (MetS) increases the risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The vitamin D receptor gene (VDR) polymorphisms have been found associated with MetS and serum 25(OH)D levels but these associations remain controversial. The aim of this study was to investigate the relationship between the VDR polymorphisms and MetS, metabolic components, and serum 25(OH)D levels within the Thai population. A case-control study included 237 participants with MetS according to the MetS diagnostic criteria of NCEP ATPIII and 376 controls. Anthropometric data, blood pressure, lipid profiles, serum 25 (OH)D, and fasting blood glucose were measured. VDR FokI, BsmI, TaqI, and Cdx2 polymorphisms were genotyped by using PCR-HRM. There were no significant differences in the frequencies of VDR genotypes and alleles between MetS and the control groups. VDR TaqI TT, and BsmI BBâ¯+â¯Bb genotypes were associated with lower 25(OH)D levels (pâ¯<â¯0.05) in comparison to TaqI Tt, and BsmI bb genotypes in the MetS group, respectively. In addition, the VDR Cdx2 GG genotype was associated with higher WC compared with the AG genotype in all subjects (pâ¯<â¯0.05). Logistic regression analysis revealed that BBâ¯+â¯Bb genotypes of the VDR BsmI had significantly increased the odds ratio (OR) of hypertriglyceridemia when compared with the bb genotype (OR 1.87; 95% CI 1.10-3.19, pâ¯=â¯0.022). In conclusion, VDR BsmI variant was associated with hypertriglyceridemia and may be predisposed to developing MetS. VDR TaqI and BsmI polymorphisms seems to influence serum 25(OH)D levels in MetS subjects, while Cdx2 polymorphism may influence WC in all subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 659, 15 June 2018, Pages 59-66
Journal: Gene - Volume 659, 15 June 2018, Pages 59-66
نویسندگان
Boonnisa Sangkaew, Manit Nuinoon, Nutjaree Jeenduang,