کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8646606 1570140 2018 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolutionary dynamics of Hepatitis C virus in a chronic HIV co-infected patient and its correlation with the immune status
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Evolutionary dynamics of Hepatitis C virus in a chronic HIV co-infected patient and its correlation with the immune status
چکیده انگلیسی
The phylogenetic analysis of the HCV-1a sequences from the studied patient showed that he was co-infected with three different viral lineages. These lineages were not evenly detected throughout time. The sequence diversity and coalescence analyses of these lineages suggested the action of different evolutionary patterns in different immune conditions: a slow rate, drift-like process in an immunocompromised condition (low levels of CD4+ T lymphocytes); and a fast rate, variant-switch process in an immunocompetent condition (high levels of CD4+ T lymphocytes).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 63, September 2018, Pages 30-38
نویسندگان
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