The chemotherapeutic potential of chalcones against leishmaniases: a review

- Antileishmanial activity of 278 synthetic chalcones and 34 chalcones of plant origin was reviewed.
- The mechanism of antileishmanial activity of chalcones was discussed.
- The structure-activity relationship of chalcones against leishmania parasites was analysed.
- Nanoparticles encapsulation of chalcones as delivery agents was examined.
- The deficiencies in this line of research were highlighted.