کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8751504 1594200 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intercellular transfer of mitochondria rescues virus-induced cell death but facilitates cell-to-cell spreading of porcine reproductive and respiratory syndrome virus
ترجمه فارسی عنوان
انتقال بین سلول های میتوکندری باعث از بین رفتن مرگ سلولی ناشی از ویروس می شود، اما گسترش سلول به سلول ویروس سندرم تولید مثل و مجرای تنفسی را تسهیل می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
Our recent study showed that intercellular tunneling nanotubes (TNTs) serve as an alternative pathway for cell-to-cell spreading of infectious materials of porcine reproductive and respiratory syndrome virus (PRRSV). In this study, we found that PRRSV infection could induce the formation of TNTs between infected and uninfected cells. Co-culturing PRRSV-infected cells with uninfected cells, including porcine umbilical cord stem cells, rescued PRRSV-induced cell death. Mitochondrion, an important regulator of cell survival/death, was observed transferring from uninfected to PRRSV-infected cells. Importantly, impaired formation of nanotube or defective mitochondrion was unable to rescue infected cells from apoptosis/necrosis. Certain PRRSV proteins were detected to associate with mitochondria and transport from infected to uninfected cells through TNTs. Our results suggest that TNTs-transfer of functional mitochondria rescued PRRSV-infected cells from apoptosis/necrosis in the early stage of infection. On the other hand, mitochondria could be utilized as a vehicle to transport viral materials for spreading the infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 517, April 2018, Pages 122-134
نویسندگان
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