کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8807705 1606640 2017 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DIMT1 overexpression correlates with progression and prognosis in gastric carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
DIMT1 overexpression correlates with progression and prognosis in gastric carcinoma
چکیده انگلیسی
We investigated the expression of dimethyladenosine transferase 1 homolog (DIMT1) in human gastric carcinoma (GC) tissues, pericarcinoma histologically normal tissues, and normal gastric tissues and explored its clinical significance. Immunohistochemistry staining was used to detect the expression of DIMT1, and the findings were compared with clinicopathological features of patients with GC. The result also was ascertained by Western blotting. The Kaplan-Meier method and log-rank test were used to compare the overall survival rate and time in the DIMT1 low-level and high-level expression groups. Immunohistochemical staining indicated that the expression of DIMT1 in GC tissues (65/75; 86.7%) was significantly more common (P < .001) than that in pericarcinoma histologically normal tissues (14/75; 18.7%) and normal gastric tissues (2/12; 16.7%). High expression of DIMT1 correlated closely with differentiation (P = .023), invasion (P = .042), lymph node metastasis (P = .008), distant metastasis (P = .006), and TNM stage (P = .013). Western blotting showed that DIMT1 expression correlated positively with TNM stage and implied that more advanced TNM stage was accompanied by higher expression of DIMT1 (P < .001). Kaplan-Meier survival analysis showed that high DIMT1 expression correlated significantly (P < .001) with a poor prognosis. Our data suggest that DIMT1 is a useful molecular biomarker to predict tumor progression and prognosis in patients with GC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 70, December 2017, Pages 35-42
نویسندگان
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