کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839818 | 1613757 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential regulation of angiogenesis in the developing mouse brain in response to exogenous activation of the hypoxia-inducible transcription factor system
ترجمه فارسی عنوان
تنظیم دیفرانسیل آنژیوژنز در مغز در حال رشد مغز در واکنش به فعال شدن خارجی سیستم فاکتور رونویسی القایی هیپوکسی
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کلمات کلیدی
PHIEPOSVZHIFCC3Angiopoietins - آنژیوپوتیین هاerythropoietin - اریتروپویتینTie-2 - تی 2hypoxia-inducible transcription factor - عامل رونویسی القایی هیپوکسیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Neuroprotection - محافظت نورونی یا محافظت از عصبsubventricular zone - منطقه فرعیHippocampus - هیپوکامپ Hypoxia - هیپوکسیhypoxic-ischemic - هیپوکسیک-ایسکمیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Angiogenesis due to hypoxic-ischemic (HI) injury represents a crucial compensatory mechanism of the developing brain that is mainly regulated by hypoxia-inducible transcription factors (HIF). Pharmacological stimulation of HIF is suggested as a neuroprotective option, however, studies of its effects on vascular development are limited. We analyzed the influence of the prolyl-4-hydroxylase inhibitor (PHI), FG-4497, and erythropoietin (rhEPO) on post-hypoxic angiogenesis (angiogenic growth factors, vessel structures) in the developing mouse brain (P7) assessed after a regeneration period of 72â¯h. Exposure to systemic hypoxia (8% O2, 6â¯h) was followed by treatment (i.p.) with rhEPO (2500/5000â¯IU/kg) at 0, 24 and 48â¯h or FG-4497 (60/100â¯mg/kg) compared to controls. In response to FG-4497 treatment cortical and hippocampal vessel area and branching were significantly increased compared to controls. This was associated with elevated ANGPT-2 as well as decreased ANGPT-1 and TIE-2 mRNA levels. In response to rhEPO, mildly increased angiogenesis was associated with elevated ANGPT-2 but also TIE-2 mRNA levels in comparison to controls. In conclusion, present data demonstrate a differential regulation of the angiopoietin/TIE-2 system in response to PHI and rhEPO in the post-hypoxic developing brain pointing to potential functional consequences for vascular regeneration and vessel development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1688, 1 June 2018, Pages 91-102
Journal: Brain Research - Volume 1688, 1 June 2018, Pages 91-102
نویسندگان
Regina Trollmann, Theresa Mühlberger, Mandy Richter, Gudrun Boie, Andreas Feigenspan, Florian Brackmann, Susan Jung,