کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8850165 | 1618663 | 2017 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of gold nanoparticles on mice splenomegaly induced by schistosomiasis mansoni
ترجمه فارسی عنوان
اثر نانوذرات طلا بر روی اسپلنومگالی موشهای ناشی از شیستوستومیوز منسونی
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کلمات کلیدی
نانوذرات طلا، شیستوسومیوز، آسیب پاره پاره، هیستوپاتولوژی، استرس اکسیداتیو، موش،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بوم شناسی
چکیده انگلیسی
Schistosomiasis is still one of the main parasitic diseases that affect human health in tropical regions. Whilst praziquantel (PZQ) is the main classic antischistosomal drug, the need for new drugs is still a must due to the low effectiveness of the drug on the schistosome young worms, and the evolving of PZQ resistant strains. Nanotechnology is one of the most important recent and current methods used to treat human diseases including parasitic ones. Therefore, the present study aimed to examine the curative role of gold nanoparticles (GNPs) on splenic tissue of mice infected with Schistosoma mansoni Sambon, 1907. High-resolution transmission electron microscopy was used for characterization of nanoparticles (NP). GNPs of 1Â mg/kg mice body weight were inoculated into mice infected with S. mansoni. The parasite caused deteriorations in histological architecture of the spleen tissue, and splenomegaly. Additionally, the parasite induced a significant reduction in splenic tissue glutathione levels; however, the concentrations of nitric oxide and malondialdehyde were significantly increased. Treatment of mice with GNPs reduced the extent of histological impairment and oxidative stress in spleen tissue. Therefore, our results demonstrate the protective role of GNPs against splenic damage in mice infected with S. mansoni.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Saudi Journal of Biological Sciences - Volume 24, Issue 6, September 2017, Pages 1418-1423
Journal: Saudi Journal of Biological Sciences - Volume 24, Issue 6, September 2017, Pages 1418-1423
نویسندگان
Mohamed A. Dkhil, Mona F. Khalil, Marwa S.M. Diab, Amira A. Bauomy, Saleh Al-Quraishy,