کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8949739 | 1645722 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AIM2 is a potential therapeutic target in human renal carcinoma and suppresses its invasion and metastasis via enhancing autophagy induction
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کلمات کلیدی
dsDNALC-3AIM2RCC3-MAASCOSCCTMA3-methyladenine - 3-متیل آدنینdouble-stranded DNA - DNA رشته ایAutophagy - اتوفاژیNSCLC - سرطان ریوی غیر سلول کوچکNon-small cell lung cancer - سرطان غیر سلول کوچک ریهTumor suppressor - سرکوبگر تومورPrognostic indicator - شاخص پیشآگهیTissue microarray - میکروآرشی بافتapoptosis-associated speck-like protein containing a caspase recruitment domain - وابسته به پروپول های وابسته به آپوپتوز، حاوی دامنه استخدام کاسپازabsent in melanoma 2 - وجود ندارد در ملانوم 2Human papillomavirus - ویروس پاپیلوم انسانیHPV - ویروس پایپلوم انسانیSquamous cell carcinoma - کارسینوم سلول سنگفرشیRenal cell carcinoma - کارسینوم سلول کلیوی یا RCC
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Absent in melanoma 2 (AIM2) as a tumor suppressor is recently recognized to play an important role in many human solid tumors. However, the biological significance and function of AIM2 in renal cell carcinoma (RCC) remain unknown. In this study, we proposed to investigate the clinicopathological and prognostic significance of AIM2 in RCC patient specimens, to analyze the correlation between AIM2 expression and disease progression, and to further investigate the role and mechanism of AIM2 in malignant behaviors of renal carcinoma by cellular and animal models. The correlation analysis showed that low AIM2 expression was significantly correlated with lymph node metastasis, poor 5-year overall (Pâ¯<â¯0.05) and disease-specific survival (Pâ¯<â¯0.05) in RCC patients. Over-expression of AIM2 in 786-O or OSRC-2 cells suppressed the cell proliferation, migration and invasion as compared with control. The increased AIM2 expression enhanced the expression of autophagy-related genes (Bcl-2, Beclin-1, LC3-â
¡, and ATG-5) and increased the ratio of LC3-â
¡/LC3-â
in renal carcinoma cells. Of note, the blockade of autophagy by 3-Methyladenine (3-MA) abrogated the inhibition of cell migration and invasion by over-expressing AIM2, indicated that AIM2 suppressed the malignant behaviors of renal carcinoma by enhancing the induction of autophagy. Furthermore, 3-MA abolished the prevention of tumor growth on nude mouse established by AIM2-OSRC-2 cells. Our results suggested that AIM2 might serve as a novel prognostic indicator as well as a potential therapeutic target for renal carcinoma treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 370, Issue 2, 15 September 2018, Pages 561-570
Journal: Experimental Cell Research - Volume 370, Issue 2, 15 September 2018, Pages 561-570
نویسندگان
Dafei Chai, Hongjian Shan, Gang Wang, Huizhong Li, Lin Fang, Jingyuan Song, Qing zhang, Jin Bai, Junnian Zheng,