کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8964147 | 1646653 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum Paraoxonase-1 Concentration as a Potential Predictor of Urinary Bladder Cancer Recurrence. A Five Year Follow-Up Study
ترجمه فارسی عنوان
غلظت پاراکسوناز-1 سرم به عنوان یک پیش بینی کننده بالقوه عود مجدد سرطان مثانه ادرار. یک مطالعه پیگیری پنج ساله
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کلمات کلیدی
بیومارکرها، پاراکسوناز-1، عود تومور، سرطان مثانه ادرار،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
This study provides preliminary information on the usefulness of measuring serum paraoxonase-1 (PON1) concentration and activity (and other inflammatory markers) to predict tumor recurrence in patients with urinary bladder cancer. We studied a total of 39 hospitalized patients in whom the diagnosis of urinary bladder cancer was confirmed by transurethral resection. After five years of follow-up, 29 patients presented with tumor recurrence. As control subjects, we also studied 61 healthy subjects and a further 132 hospitalized patients who had a urinary catheter-related infection due to causes other than cancer. Results showed that urinary bladder patients had lower serum PON1 concentration and activity, and higher chemokine (C-C motif) ligand 2, C-reactive protein, and procalcitonin concentrations than the control individuals. Patients with tumor recurrence had significantly lower serum PON1 concentration than patients without tumor recurrence. The mean area under the curve of the receiver operating characteristics plot for serum PON1 concentration in discriminating patients with and those without tumor recurrence was 0.755 and the best combination of sensitivity and specificity was obtained at PON1 = 100 mg/L (0.72 and 0.80, respectively). Establishing this value as a cut-off, positive predictive value was = 0.91, and negative predictive value was = 0.50. These results suggest that the measurement of serum PON1 concentration may be a high-sensitivity marker of tumor recurrence in urinary bladder cancer patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Medical Research - Volume 49, Issue 2, February 2018, Pages 119-122
Journal: Archives of Medical Research - Volume 49, Issue 2, February 2018, Pages 119-122
نویسندگان
Simona Iftimie, Anabel GarcÃa-Heredia, Francesc Pujol-Bosch, Antoni Pont-Salvadó, Ana Felisa López-Azcona, Anna Hernández-Aguilera, Noemà Cabré, Fedra Luciano-Mateo, Isabel Fort-Gallifa, Antoni Castro, Jordi Camps, Jorge Joven,