کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
936687 1475179 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Offline consolidation of memory varies with time in slow wave sleep and can be accelerated by cuing memory reactivations
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Offline consolidation of memory varies with time in slow wave sleep and can be accelerated by cuing memory reactivations
چکیده انگلیسی

Memory representations are reactivated during slow-wave sleep (SWS) after learning, and these reactivations cause a beneficial effect of sleep for memory consolidation. Memory reactivations can also be externally triggered during sleep by associated cues which enhance the sleep-dependent memory consolidation process. Here, we compared in humans the influence of sleep periods (i) of 40 min and (ii) of 90 min without externally triggered reactivations and (iii) of externally triggered reactivations by an associated odor cue during a 40-min sleep period on the consolidation of previously learned hippocampus-dependent visuo-spatial memories. We show that external reactivation by an odor cue during the 40-min sleep period enhanced memory stability to the same extent as 90 min of sleep without odor reactivation. In contrast, 40 min of sleep without external reactivations were not sufficient to benefit memory. In the 90-min sleep condition, memory enhancements were associated with time spent in SWS and were independent of the presence or absence of REM sleep. These results suggest that the efficacy of hippocampus-dependent memory consolidation depends on the duration of sleep and particularly SWS. External reactivation cues can accelerate the consolidation process even during shorter sleep episodes.


► Comparing natural sleep and externally triggered memory reactivations during sleep.
► The memory benefit of sleep varies with time in SWS and slow oscillation power.
► External reactivation triggers can accelerate reactivation processes during sleep.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 98, Issue 2, September 2012, Pages 103–111
نویسندگان
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