کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
939280 1475379 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Energy homeostasis and appetite regulating hormones as predictors of weight loss in men and women
ترجمه فارسی عنوان
هموستاز انرژی و هورمون های تنظیم کننده اشتها به عنوان پیش بینی کننده کاهش وزن در مردان و زنان
کلمات کلیدی
تفاوت جنسیتی؛ هورمون های اشتها. کاهش وزن
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی

Sex differences in weight loss are often seen despite using the same weight loss program. There has been relatively little investigation of physiological influences on weight loss success in males and females, such as energy homeostasis and appetite regulating hormones. The aims were to 1) characterise baseline plasma leptin, ghrelin and adiponectin concentrations in overweight and obese males and females, and 2) determine whether baseline concentrations of these hormones predict weight loss in males and females.Subjects were overweight or obese (BMI 25–40 kg/m2) adults aged 18–60 years. Weight was measured at baseline, and after three and six months participation in a weight loss program. Baseline concentrations of leptin, adiponectin and ghrelin were determined by enzyme-linked immunosorbent assay (ELISA). An independent t-test or non-parametric equivalent was used to determine any differences between sex. Linear regression determined whether baseline hormone concentrations were predictors of six-month weight change.Females had significantly higher baseline concentrations of leptin, adiponectin and unacylated ghrelin as well as ratios of leptin:adiponectin and leptin:ghrelin. The ratio of acylated:unacylated ghrelin was significantly higher in males. In males and females, a higher baseline concentration of unacylated ghrelin predicted greater weight loss at six months. Additionally in females, higher baseline total ghrelin predicted greater weight loss and a higher ratio of leptin:ghrelin predicted weight gain at six months.A higher pre-weight-loss plasma concentration of unacylated ghrelin is a modest predictor of weight loss success in males and females, while a higher leptin:ghrelin ratio is a predictor of weight loss failure in females. Further investigation is required into what combinations and concentrations of these hormones are optimal for weight loss success.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Appetite - Volume 101, 1 June 2016, Pages 1–7
نویسندگان
, , , , ,