کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9954454 1547855 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extracellular vesicles-mediated signaling in the osteosarcoma microenvironment: Roles and potential therapeutic targets
ترجمه فارسی عنوان
سیگنالینگ واسکیل های غیر سلولی در محیط میکرو محیط استئوسارکوم: اهداف و اهداف درمان بالقوه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Osteosarcoma (OS) is the most common non-hematologic malignant tumor of bone in children. It is usually characterized by a high risk of developing lung metastasis and poor prognosis. Extracellular vesicles (EVs) are cell-derived nanoparticles with a small size of 50-200 nm in diameter. As a communicator, the contents of the EVs secreted via either fusing with lysosomes for degradation and recycling or fusing with the cell plasma membrane into the extracellular environment, which play an important role in regulating the tumor microenvironment of OS and mediating the Wnt/β-catenin and TGF-β signalings. Increasing evidences suggest that EVs have significant role in OS growth, progression, metastasis and drug resistance. In this study, the roles of EVs in the physiology and pathogenesis of OS and the potential attractive therapeutic target for the treatment of OS were reviewed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Bone Oncology - Volume 12, September 2018, Pages 101-104
نویسندگان
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