Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β protein; AD, Alzheimer's disease; ApoE, apolipoprotein E; APP, amyloid precursor protein; BACE1, β-secretase; CI, confidence interval; CN, cognitively normal; FPP, farnesyl pyrophosphate; FTI, farnesyl transferase inhibitor; GGPP, geranylger
مقالات ISI APP، پروتئین پیش ماده آمیلوئید (ترجمه نشده)
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Keywords: APP، پروتئین پیش ماده آمیلوئید; α-syn, α-synuclein; Aβ, amyloid β; AD, Alzheimer disease; APP, amyloid precursor protein; a-SMase, acid sphingomyelinase; alk-SMase, Alkaline SMase; Cer, ceramide; CERT, ceramide transfer protein; CSF, cerebrospinal fluid; D609, tricyclodecan-9-yl-xanthog
Keywords: APP، پروتئین پیش ماده آمیلوئید; Alzheimer's disease; Amyloid cascade; Protein aggregation; Beta amyloid dimer; Amyloidogenic; Molecular docking; Steric-zipper assemblyAD, Alzheimer's disease; Aβ, Beta amyloid; NFT, Neurofibrillary tangles; APP, Amyloid precursor protein; CNS, Central ne
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; BBB, blood-brain barrier; BSB, blood-spinal cord barrier; C1-Inh/C1-INH, C1 complex inhibitor; CNS, central nervous system; CR1, complement receptor 1; CR2, compl
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; APP, amyloid precursor protein; ApoE4, apolipoprotein E ɛ4; aPKC, atypical protein kinase C; BLBP, brain lipid-binding protein; BrdU, 5-bromo-2′-deoxyuridine; CREB, cAMP response element binding protein; CSF, cerebrospinal fluid;
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; AS, α-synuclein; ASD, Autism spectrum disorder; ADK, adenosine kinase; ATP, adenosine triphosphate; AxD, Alexander disease; CD81, Cluster of Differentiation 81; C
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; AMPAR, AMPA receptor; ADEM, acute disseminated encephalomyelitis; APP, amyloid precursor protein; CBD, cortico-basal degeneration; DH
Keywords: APP، پروتئین پیش ماده آمیلوئید; 6-OHDA, 6-hydroxydopamine; ABP, actin binding protein; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; Aβ, amyloid-β; Cdk5, cyclin-dependent kinase 5; CMT, Charcot-Marie-Tooth disease; CMT2, Charcot-Marie-Tooth
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer’s disease; Aβ, β amyloid; PD, Parkinson disease; l-DOPA, l-dihydroxyphenylalanine; LBs, Lewy bodies; DA, dopamine; APP, amyloid precursor protein; CVD, cardiovascular diseaseNeurological disorders; Alzheimer’s disease; Parkinson disease; Car
Keywords: APP، پروتئین پیش ماده آمیلوئید; Alzheimer's disease; Gold nanoparticle; Cell cycleAD, Alzheimer's disease; Aβ, β-amyloid peptide; APP, amyloid precursor protein; GNP, gold nanoparticle; SA, streptavidin; HRP, horseradish peroxidase; pAb, polyclonal antibody; IgG, immunoglobulin G; DMEM,
Keywords: APP، پروتئین پیش ماده آمیلوئید; Alzheimer's disease; Acetylcholinesterase inhibitors; N-methyl d-aspartate receptor antagonist; Beta amyloid; Neurofibrillary tanglesAD, Alzheimer's disease; APP, amyloid precursor protein; ApoE, apolipoprotein E; ACh, acetylcholine; AChEs, acetylcholines
Keywords: APP، پروتئین پیش ماده آمیلوئید; APP, amyloid precursor protein; EGCG, epigallocatechin-3-gallate; MCI, mild cognitive impairment; MMSE, mini-mental state examination; PKC, protein kinase C; ROS, reactive oxygen speciesGreen tea; Catechin; Cognitive disorders; Epidemiology; Intervention
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer’s disease; ALDH2, aldehyde dehydrogenase 2; APP, amyloid precursor protein; BMMC, bone marrow-derived mononuclear cellIntravenous transplantation; Mononuclear cell; Amyloid-β; Neurodegeneration; Alzheimer’s disease
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; APP, amyloid precursor protein; BACE1, beta-site APP-cleaving enzyme 1; HPT, hypothalamus–pituitary–thyroid; IFN-γ, interferon-γ; LPS, lipopolysaccharide; pGlu, pyroglutamate; QC, glutaminyl cyclase; TRH, thyrotropin-releasing hor
Keywords: APP، پروتئین پیش ماده آمیلوئید; arterial stiffness; biomarker; risk stratification; subclinical atherosclerosisAbeta40, amyloid-beta 1-40; APP, amyloid precursor protein; CHD, coronary heart disease; CV, cardiovascular; eGFR, estimated glomerular filtration rate; hsCRP, high-sensitivity
Keywords: APP، پروتئین پیش ماده آمیلوئید; ABC, ATP-binding cassette; AβOs, Aβ oligomers; AD, Alzheimer's disease; APP, amyloid precursor protein; DHBA, dihydroxybenzoic acid; CALG, calcein green; DMT1, divalent metal transporter 1; FA, Friedreich's ataxia; FPN1, ferroportin 1; IRP1, iron-regulato
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer׳s disease; Ala, alanine; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; APP/PS1, Aβ overexpressing mice APP (K670N/M671L) and PS1 (M146L) mutants; AppLon, London familial amyloid precursor protein mutation, APP (V717I);
Keywords: APP، پروتئین پیش ماده آمیلوئید; ADAMTS-4/5, a disintegrin and metalloproteinase with thrombospondin motifs 4 and 5; ApoER2, apoE receptor 2; APP, amyloid precursor protein; BDNF, brain-derived neurotrophic factor; DIFP, diisopropyl fluorophosphate; LTP, long-term potentiation; PAI-1, pl
Keywords: APP، پروتئین پیش ماده آمیلوئید; Acetylcholinesterase; Alzheimer's disease; Antioxidant activity; BACE-1; Benzophenone; Drug design; Lead identificationAChE, acetylcholinesterase; AD, Alzheimer's disease; ABP, aminobenzylpiperidine; Aβ, amyloid-β; APP, amyloid precursor protein; BACE-1,
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid-β; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; BLG, Basso mouse scale/Ladder climb/Grid walk; BMS, Basso mouse scale; DAPT, N-[(3, 5-Difluorophenyl)acetyl]-l-alanyl-2-phenylglycine-1,1-dimethylethyl ester; DEA, diethyla
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, β-amyloid; AD, Alzheimer's disease; APP, amyloid precursor protein; CDK, cyclin dependent kinase; ECM, extracellular matrix; ERK, extracellular signal-regulated protein kinase; GSK, glycogen synthase kinase; MSD, Meso Scale DiscoveryAlzheimer's diseas
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; Aβ, amyloid-β; APP, amyloid precursor protein; Arg1, arginase 1; BrdU, 5-bromo-2′-deoxyuridine; CBD, calbindin; CsA, cyclosporin A; DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride; DCX, doublecortin; GAD65, glutamate decarboxy
Keywords: APP، پروتئین پیش ماده آمیلوئید; Alzheimer's disease; Fragile X syndrome; Glycogen synthase kinase-3; Learning; Lithium; LTPAD, Alzheimer's disease; Aβ, amyloid-β peptide; APP, amyloid precursor protein; CNS, central nervous system; FX, Fragile X; GSK3, glycogen synthase kinase-3; LTD, l
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer’s disease; APP, amyloid precursor protein; CGI, CpG islands; CBP, CREB-binding protein; DNMTs, DNA methyltransferases; ESCs, embryonic stem cells; GFAP, glial fibrillary acidic protein; HATs, histone acetyl transferases; HDACs, histone deace
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β; AD, Alzheimer's disease; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; APP, amyloid precursor protein; Atox 1, human antioxidant protein 1; Atx1, antioxidant protein 1; BBB, blood–brain barrier; BCB, blood–cerebrospinal fluid
Keywords: APP، پروتئین پیش ماده آمیلوئید; WT, wild type; Tg, transgenic; pSTR, positive scotopic threshold response; ERG, electroretinogram; IOP, intraocular pressure; GCL, ganglion cell layer; IPL, inner plexiform layer; AD, Alzheimer’s disease; APP, amyloid precursor protein; PSEN, presenilineA
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid-β; AD, Alzheimers’ disease; AICD, APP intracellular domain; APP, amyloid precursor protein; ATM/ATR, ataxia telangiectasia mutated/ataxia-telangiectasia-and Rad3-related; BCA, bicinchoninic acid; CHO, Chinese hamster ovary; CPI, complete prote
Estrogen induced the expression of ADAM9 through estrogen receptor α but not estrogen receptor β in cultured human neuronal cells
Keywords: APP، پروتئین پیش ماده آمیلوئید; ADAM9; ERα; ERβ; SH-SY5Y cells; Alzheimer's diseaseAD, Alzheimer's disease; β-Aβ, Amyloid; ADAM, ‘a disintegrin and metalloprotease’ family of proteinases; APP, amyloid precursor protein; sAPPα, Aoluble N-terminal APP fragments; ER, estrogen receptor; DME
The pathogenesis of soluble PrP fragments containing Aβ binding sites
Keywords: APP، پروتئین پیش ماده آمیلوئید; PD, prion diseases; AD, Alzheimer’s disease; PrP, prion protein; GSS, Gerstmann–Sträussler–Scheinker; GPI, glycosyl-phosphatidylinositol; APP, amyloid precursor protein; LTP, long-term potentiation; CJD, Creutzfeldt–Jakob diseaseSoluble PrP95-105; Amyloid
Cell-free expression of the APP transmembrane fragments with Alzheimer's disease mutations using algal amino acid mixture for structural NMR studies
Keywords: APP، پروتئین پیش ماده آمیلوئید; Amyloid precursor protein; Alzheimer's disease mutations; Transmembrane domain; Cell-free expression system; Algal mixture; NMR spectroscopyAD, Alzheimer's disease; APP, amyloid precursor protein; MP, membrane proteins; DPC, dodecylphosphocholine; HSQC, H
The anti-dementia drug candidate, (−)-clausenamide, improves memory impairment through its multi-target effect
Keywords: APP، پروتئین پیش ماده آمیلوئید; Chirality; Clausenamide; Dementia; Long-term potentiation; Signaling pathway; Calcium6-OHDA, 6-hydroxyldopamine; ACE, acetylcholinesterase; ACh, acetylcholine; AD, Alzheimer's disease; AUC0–12 h, 0–12 h area under curve; APP, amyloid precursor protein; AP
Gene expression profiles of autophagy-related genes in multiple sclerosis
Keywords: APP، پروتئین پیش ماده آمیلوئید; AMBRA1, activating molecule in Beclin-1-regulated autophagy protein 1; APP, amyloid precursor protein; ATG, autophagy genes; cDNA, complementary DNA; DAPK, death-associated protein kinase; dNTP, deoxyribonucleic acid; DRAM1, DNA damage-regulated autophagy
Characterization of F-spondin in Japanese flounder (Paralichthys olivaceus) and its role in the nervous system development of teleosts
Keywords: APP، پروتئین پیش ماده آمیلوئید; ECM, extracellular matrix; TSRs, thrombospondin repeats; APP, amyloid precursor protein; AD, Alzheimer disease; ISH, in situ hybridization; DIG, digoxigenin; SEM, standard error of the mean; ORF, open reading frame; TSR1, thrombospondin type 1 repeatJapan
TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, β-amyloid protein; AD, Alzheimer’s disease; APP, amyloid precursor protein; BACE, β-site APP cleaving enzyme; BDNF, brain-derived neurophic factor; COX, cyclooxygenase; IDE, insulin-degrading enzyme; LPS, lipopolysaccharide; MWM, Morris water maze; SE
Alzheimer's disease genes and autophagy
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; APP, amyloid precursor protein; Aβ, β-amyloid; PS1/2, presenilin 1/2, ApoE, apolipoprotein E; ADAM10, a disintegrin and metallopeptidase domain 10; TREM2, triggering receptor expressed on myeloid cells 2; BECN1, beclin-1; SNP, sin
AMP18 interacts with the anion exchanger SLC26A3 and enhances its expression in gastric cancer cells
Keywords: APP، پروتئین پیش ماده آمیلوئید; Antrum mucosal protein; Gastric cancer; Brichos domain; Down-Regulated in AdenomaAPM18, antrum mucosal protein of 18 kDa; APP, amyloid precursor protein; GC, gastric cancer; DRA, Down-Regulated in Adenoma; GAPDH, glyceraldheyde-3-phosphate dehydrogenase;
Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, β-amyloid; ACSF, artificial cerebrospinal fluid; AD, Alzheimer׳s disease; APP, amyloid precursor protein; Ca2+, calcium ion; CTF, C terminal fragment; DKO, double knockout; DMSO, dimethyl sulfoxide; ER, endoplasmic reticulum; FAD, familial early-onset
Piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels via activation of alpha-secretase and matrix metalloproteinase-9
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; Aβ, beta-amyloid; APP, amyloid precursor protein; APPsw, APP Swedish mutant; NEP, neprilysin or neutral endopeptidase; IDE, insulin degrading enzyme; MMP-9, matrix metalloproteinase-9; HEK293, human embryonic kidney 293; CTF, carb
Post-ischemic treatment of WIB801C, standardized Cordyceps extract, reduces cerebral ischemic injury via inhibition of inflammatory cell migration
Keywords: APP، پروتئین پیش ماده آمیلوئید; A3AR, A3 adenosine receptor; APP, amyloid precursor protein; BBB, blood-brain barrier; CBF, cerebral blood flow; EB, evans blue; MBP, myelin basic protein; MCAO, middle cerebral artery Occlusion; MCP-1, monocyte chemoattractant protein-1; PFA, paraformald
Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against β-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats
Keywords: APP، پروتئین پیش ماده آمیلوئید; AA, arachidonic acid; AChE, acetylcholinesterase; AD, Alzheimer's disease; APP, amyloid precursor protein; COX, cyclooxygenase; ELT, escape latency time; ICV, intracerebroventricular; LOX, lipoxygenase; MDA, malondialdehyde; MWM, Morris water-maze; NSAID,
Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β peptide; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; ARF6, ADP-ribosylation factor-6; AZ, active zone; CME, clathrin-mediated endocytosis; dMVB, multivesicular body involved in the degradation pathway; EE, early endos
Pharmacological properties of a novel and potent γ-secretase modulator as a therapeutic option for the treatment of Alzheimer’s disease
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, Amyloid-β; AD, Alzheimer’s disease; APP, Amyloid precursor protein; β-CTF, β-C-terminal fragment; BACE, β-site APP-cleaving enzyme; CSF, Cerebrospinal fluid; ELISA, Enzyme-linked immunosorbent assay; FBS, Fetal bovine serum; GSI, γ-secretase inhibitor
GluN2B-containing NMDA receptors contribute to the beneficial effects of hydrogen sulfide on cognitive and synaptic plasticity deficits in APP/PS1 transgenic mice
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, beta-amyloid; ACSF, artificial cerebrospinal fluid; AD, Alzheimer’s disease; ANOVA, analysis of variance; APP, amyloid precursor protein; BDNF, brain derived neurotrophic factor; BS3, bis(sulfosuccinimidyl)suberate; CaMKII, calcium/calmodulin-activate
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease
Keywords: APP، پروتئین پیش ماده آمیلوئید; ADAM, A Disintegrin and Metalloproteinase Domain; APP, amyloid precursor protein; BACE, Beta-site APP cleaving enzyme 1; BSA, bovine serum albumin; CamKIIα, Ca2 +/calmodulin-dependent protein kinase II alpha; COFRADIC, combined fractional diagonal chromat
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2)
Keywords: APP، پروتئین پیش ماده آمیلوئید; GSM, γ-secretase modulator; Aβ, amyloid beta; AD, Alzheimer’s disease; LLE, ligand-lipophilicity efficiency; NORT, novel object recognition test; APP, amyloid precursor protein; MLM, mice liver microsomes; CNS, central nervous system; WT, wild typeAlzheim
Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; Aβ, amyloid-beta; APP, amyloid precursor protein; GABA, gamma-aminobutyric acid; GFAP, glial fibrillary acidic protein; IF, intermediate filament; VIM, vimentin; TNFα, tumor necrosis factor α; BBB, blood brain barrier; EC, entorhi
A membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes
Keywords: APP، پروتئین پیش ماده آمیلوئید; TM, transmembrane domain; CT, cytosolic domain; APP, amyloid precursor protein; AD, Alzheimer's disease; MBP, maltose binding protein; DMPC, 1,2-dimyristoyl-sn-glycerophosphocholine; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; 1,2-DOG, 1,2-dioleo
Study of early stages of amyloid Aβ13-23 formation using molecular dynamics simulation in implicit environments
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, β-amyloid; AD, Alzheimer’s disease; APP, amyloid precursor protein; DOPS, dioleoylphosphatidylserine; DPPC, dipalmitoylphosphatidylcholine; HBimbb, intermolecular backbone hydrogen bonds; HFIP, hexafluoroisopropanol; MD, molecular dynamics; PDB, Prote
Neuroprotective action of resveratrol
Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, beta-amyloid; AD, Alzheimer's disease; AIF, Apoptosis Inducing Factor; AMPK, AMP-activated protein kinase; AP-1, activator protein-1; BBB, blood-brain barrier; COX, cyclooxygenase; APP, amyloid precursor protein; ERK1/2, extracellular signal-regulated
A strategy focused on MAPT, APP, NCSTN and BACE1 to build blood classifiers for Alzheimer׳s disease
Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer׳s disease; APP, amyloid precursor protein; Aβ, amyloid-beta peptides; BACE1, β-site APP cleaving enzyme; C&RTs, classification and regression trees; MAPT, microtubule-associated protein tau; NCSTN, γ-secretase subunit nicastrin; NP, non-AD n