Keywords: AL; alantolactone; AL-GSH; glutathione conjugate of alantolactone; AL-Cys; cysteine conjugate of alantolactone; AUC; area under the concentration-time curve; Cys; cysteine; CYP450; cytochrome P450; DAD; diode array detector; GSH; glutathione; GST; glutath
مقالات ISI (ترجمه نشده)
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Keywords: Genetic; Depression; CYP450; Pharmacodynamics; Pharmacokinetics; Antidepressant; Pharmacogenetics; Pharmacogenomics; Cost-effectiveness; Genesight; CNSDose;
Keywords: 2D-sw; 2D-sandwich; AMI; amiodarone; APAP; acetaminophen; BA; bile acid; BC; bile canaliculi; BOS; bosentan; BSEP; bile salt export pump; CPZ; chlorpromazine; CSA; cyclosporine A; CYP450; cytochrome P450; DIC; drug-induced cholestasis; DICI; drug-induced
Keywords: Car3; carbonic anhydrase 3; CAT; Catalase; CK; control check; CYP450; cytochrome P450; DAVID; Database for Annotation, Visualization and Integrated Discovery; DTNB; 5,5â²-dithiobis-(2-nitrobenzoic acid); FB; fava bean; G6P; d-glucose-6-phosphate; G6PD; g
Keywords: ALS; amyotrophic lateral sclerosis; BDNF; brain-derived neurotropic factor; CerS; ceramide synthase; CNS; central nervous system; CPL; cecal ligation and puncture; cPLA2; cytosolic phospholipase A2; CSA; cyclosporine A; CTL; cytotoxic T lymphocytes; CYP45
Keywords: AA; arachidonic acid; COX; cyclooxygenase; cPGES; cytoplasmic prostaglandin E synthase; CREB; carbohydrate response element binding protein; CYP450; CYP450 epoxygenase; DAG; diacylglycerol; EGFR; epidermal growth factor receptor; EGFRvIII; epidermal growt
Keywords: CYP450; Metabolic clearance; Drug-drug interactions; Abiraterone; Enzalutamide; Prostate cancer;
Keywords: LA; Linoleic acid; AA; Arachidonic acid; IS; Internal standard; LOX; Lipoxygenase; COX; Cyclooxygenase; CYP450; Cytochrome P450; HODE; hydroxyl-octadecadienoic acid; KODE; oxo-octadecadienoic acid; Tetranor-PGEM; tetranor-prostaglandin E metabolite; TX; t
Keywords: AA; arachidonic acid; ASA; acetylsalicylic acid; C. albicans; Candida albicans; CFU; colony forming unit; COX; cyclooxygenase; CYP450; cytochrome P450 monooxygenase; ELISA; enzyme-linked immunosorbent assay; EPS; exopolysaccharide; ExoU; exotoxin U; NDGA;
Keywords: AD; Alzheimer's disease; ARA; arachidonic acid; COX; cyclooxygenase; CYP450; cytochrome P450; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; EETs; epoxyeicosatrienoic acids; EpFAs; epoxy-fatty acids; ER Stress; endoplasmic reticulum stress; IBD; i
Capillary electrophoresis in the context of drug discovery
Keywords: ACE; affinity capillary electrophoresis; AGP; α-acid glycoprotein; AH; adrenaline hydrochloride; AIμEA; automatic micro-enzyme assay; AL; amlodipine; AT; antithrombin III; Bag3; Bcl2-associated anthanogene 3; BGE; background electrolyte; CM; chylomicron
Keywords: Natural products; Dietary supplements; Herbal medicines; Drug interactions; Cytochrome P450; Transporters; Metabolic enzymes; CYP450; cytochrome P450; Cmax; maximum concentration; DDI; drug-drug interactions; MDP; methylenedioxyphenyl; NP; natural produ
Keywords: Lipid apheresis; Hyperlipoproteinaemia; Gas chromatography; Oxylipine; Lipidomic; LC/ESI-MS/MS; PUFA; n-3-PUFA; omega-3 polyunsaturated fatty acids; n-6-PUFA; omega-6 polyunsaturated fatty acids; EPA; eicosapentaenoic acid; DHA; docosahexaenoic acid; AA;
Keywords: Y maze; Brain; TNO; Ca ATPase; CYP450; FABP7;
Keywords: Dictamnine; Metabolism; Liver microsomes; CYP450; Mass spectrometry
Keywords: PAPS; 3â²-Phosphoadenosine 5â²-phosphosulfate; DTNB; 5,5â²-Dithiobis(2-nitrobenzoic acid); APAP; Acetaminophen; ALT; Alanine aminotrasferase; BSA; Bovine serum albumin; CCl4; Carbon tetrachloride; Ccr2; C-C chemokine receptor 2; CFB; Clofibrate; CD;
Keywords: 17β-HSD; 17-beta hydroxysteroid dehydrogenase; MLHI; MutL Ecoli homolog 1; 2,5-HD; 2,5-n-hexandione; MMPs; Matrix metalloproteinases; AHr; Aryl Hydrocarbon receptor; MRP1; Multi-drug Resistance protein 1; Akr1c; Aldo-keto reductase family; NF-κβ; Nucle
Keywords: ALT; alanine transaminase; AST; aspartate transaminase; BMI; body mass index; CLD; congenital leptin deficiency; Cmax; peak serum concentration; CYP450; cytochrome P450; DXA; dual-energy X-ray absorptiometry; FGF21; fibroblast growth factor 21; FSH; folli
Keywords: HMG-CoA reductase inhibitors; Statins; Mycetes; LDL receptors; Hypercholesterolemia; CYP450; OATP
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; antiChE; anticholinesterase; CYP450; cytochrome P450; GABA; γ-aminobutyric acid; MC; methylcarbamate; nAChR; nicotinic acetylcholine receptor; OP; organophosphorus; PC; propylcarbamate; WT; wild type; Acety
Keywords: AA; arachidonic acid; ASO; refined high-oleic sunflower oil enriched with an olive-pomace extract of phenols; BI; before intake; COX; cyclooxygenase; CYP450; cytochrome P450 monooxygenase; DSO; refined high-oleic sunflower oil enriched with 400 μg/mL of
Keywords: 3-HB; 3-Hydroxybutyrate; ALP; alkaline phosphatase; ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; ATP; adenosine-5â²-triphosphate; CHOL; cholesterol; CTRL; control; CYP450; cytochrome P450; GGT; γ-glutamyl transfer
A UHPLC-MS/MS method coupled with liquid-liquid extraction for the quantitation of phenacetin, omeprazole, metoprolol, midazolam and their metabolites in rat plasma and its application to the study of four CYP450 activities
Keywords: ACE; acetaminophen; PHE; phenacetin; OHOME; 5â²-hydroxy omeprazole; OME; omeprazole; OHMET; α-hydroxy metoprolol; MET; metoprolol; OHMDZ; 1â²-hydroxy midazolam; MDZ; midazolam; CYP450; Probe drug; Metabolite; UHPLC-MS/MS; DDI; 3-n-butylphthalide;
Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
Keywords: CYP450; CYP2C9 variants; Synthetic cannabinoids; Enzyme kinetics; Toxicity; Î9-THC; (â)-Î9-Tetrahydrocannabinol; P450; cytochrome P450; CYP; specific P450; UGTs; uridine diphosphate (UDP)-glucuronosyltransferases; LC-MS/MS; Liquid chromatography-tande
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice
Keywords: Naringenin; Diabetes; Cardiac hypertrophy; PPARs; EETs; CYP2J3; AA; arachidonic acid; ANF; atrial natriuretic factor; BW; body weight; CVF; collagen volume fraction; CYP450; cytochrome P450; DCM; diabetic cardiomyopathy; DHM; diabetic cardiac hypertrophy
PXR polymorphisms have impact on the clinical efficacy of clopidogrel in patients undergoing percutaneous coronary intervention
Keywords: ABCB1; ATP-binding cassette, sub-family B, member 1; ACEI; angiotensinconverting enzyme inhibitor; ADP; adenosine diphosphate; ARB; angiotensin receptor blocker; CCB; calcium channel blockers; CHD; Coronary Heart Disease; CLP; clopidogrel; CLPM; clopidogr
Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development
Keywords: PD; Parkinson disease; DA; Dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; HVA; Homovanillic acid; BBB; blood brain barrier; sEH; soluble epoxide hydrolase; mEH; microsomal epoxide hydroxylases; COX-2; cyclooxygenase-2; ROS; reactive oxygen species; AA;
Metabolism of liver CYP450 and ultrastructural changes after long-term administration of aspirin and ibuprofen
Keywords: Liver; Aspirin; Ibuprofen; CYP450; Rat;
Functional characterization of naturally occurring wild soybean mutant (sg-5) lacking astringent saponins using whole genome sequencing approach
Keywords: Astringent saponins; CYP72A69; Soybean; G. soja; CYP450;
Dupilumab: A review of its use in the treatment of atopic dermatitis
Keywords: biologics; dupilumab; IL-4; IL-13; IL-4Rα; moderate-to-severe atopic dermatitis; systemic therapy; AD; atopic dermatitis; ADA; antidrug antibody; CCL; C-C motif chemokine ligand; CYP450; cytochrome P450; DLQI; Dermatology Life Quality Index; EASI; Eczema
Modulation of Cyp450, ALS1 and COX-2 signaling pathways induced by Candida albicans infection via novel antifungal agents
Keywords: Candida albicans; Fluconazole; Cyp450; ALS1; COX-2;
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro
Keywords: Nuclear factor erythroid-2-related factor 2 (Nrf2); Acetaminophen (APAP); Acute liver injury; Oxidative stress; Ginsenoside Rg1; ALT; alanine transaminase; ARE; antioxidant element; AST; aspartate transaminase; CAT; catalase; GCL; glutamate-cysteine ligas
Gene expression analysis of Ruditapes philippinarum haemocytes after experimental Perkinsus olseni zoospore challenge and infection in the wild
Keywords: Manila clam; Perkinsosis; Oligo-microarray; Immune response; Host-parasite interaction; A2ML1; Alpha-2-macroglobulin; ABL1; Tyrosine-protein kinase abl1; ACTA2; Alpha-2 actin; ACTB; Beta-actin; ALG1; Chitobiosyldiphosphodolichol beta-mannosyltransferase;
Metabolism-dependent cytotoxicity of citrinin and ochratoxin A alone and in combination as assessed adopting integrated discrete multiple organ co-culture (IdMOC)
Keywords: AFB1; aflatoxin B1; CTN; citrinin; CYP450; cytochrome P450; DMSO; dimethyl sulfoxide; IC50; the concentration at which 50% of cells are dead; IdMOC; integrated discrete multiple organ co-culture; MTT; 3-4,5-dimethylthiazole-2-yl, 2,5-diphenyl tetrazolium
Lead modulated Heme synthesis inducing oxidative stress mediated Genotoxicity in Drosophila melanogaster
Keywords: δ-aminolevulinic acid dehydratase; δ-aminolevulinic acid; CYP450; Wing spot test; Comet assay;
Longitudinal expression patterns of HMGR, FPS, SS, SE and DS and their correlations with saponin contents in green-purple transitional aerial stems of Panax notoginseng
Keywords: ANOVA; analysis of variance; Ct; cycle threshold value; CYP450; cytochrome P450; DS; dammarenediol synthase gene; DS; dammarenediol synthase; FPS; farnesyl pyrophosphate synthase gene; FPS; farnesyl pyrophosphate synthase; GAPDH; glyceraldehyde phosphate
De novo root transcriptome of a medicinally important rare tree Oroxylum indicum for characterization of the flavonoid biosynthesis pathway
Keywords: Flavonoid; Oroxylum indicum (Bignoniaceae); Metabolic pathway; MBW complex; CYP450; Baicalein; Flavone synthase;
Genetic variation of cytochrome P450 in Uyghur Chinese population
Keywords: Uyghur; CYP450; Genetic polymorphisms; Chinese; Drug response;
Repeated administration of Sailuotong, a fixed combination of Panax ginseng, Ginkgo biloba, and Crocus sativus extracts for vascular dementia, alters CYP450 activities in rats
Keywords: Sailuotong; Panax ginseng; Ginkgo biloba; Crocus sativus; CYP450; Herb-drug interaction; Abbreviation: SLT; Sailuotong; VD; vascular dementia; TCM; traditional Chinese medicines; DDI; drug-drug interaction; CYP450; cytochrome P450; SPE; solid phase extrac
Improving oral bioavailability of resveratrol by a UDP-glucuronosyltransferase inhibitory excipient-based self-microemulsion
Keywords: ACN; acetonitrile; AP; apical; BL; basolateral; CYP450; cytochrome P450 proteins; FBS; fetal bovine serum; IC50; half-inhibitory concentration; MEM; minimum essential medium; MTT; 3-(40,50-dimethylthiazol-20-yl)-2,5-diphenyltetrazolium bromide; NEAA; none
GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding
Keywords: au; arbitrary units; BBB; blood brain barrier; CNS; central nervous system; CYP450; cytochrome P450; DMSO; dimethyl sulfoxide; ESI; electrospray ionization; GABAA; γ- aminobutyric acid type A receptor; HPLC; high performance liquid chromatography; HR; hi
Bush mint (Hyptis suaveolens) and spreading hogweed (Boerhavia diffusa) medicinal plant extracts differentially affect activities of CYP1A2, CYP2D6 and CYP3A4 enzymes
Keywords: CYP450; Herb-drug interaction; Time-dependent inhibition; Ki; Hyptis suaveolens; Boerhavia diffusa; Flourimetric assay; Medicinal herb; Polyphenolic compounds; UPLC-MS;
In-vitro metabolism, CYP profiling and metabolite identification of E- and Z- guggulsterone, a potent hypolipidmic agent
Keywords: 1-ABZT; 1-aminobenzotriazole; CYP450; cytochrome P450; HLM; human liver microsomes; IS; internal standard; LC-MS/MS; liquid chromatography-tandem mass spectrometry; NADPH; reduced form of nicotinamide adenine dinucleotide phosphate; HPLC; high-performan
In vitro metabolism of desomorphine
Keywords: Desomorphine; Krokodil; Metabolism; CYP450; Isoenzymes;
Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response
Keywords: AD; atopic dermatitis; CYP450; cytochrome P450; DC; dendritic cell; ILC; innate lymphoid cell; ILCs2; type 2 innate lymphoid cells; K14; keratin 14; PXR; pregnane X receptor; TEWL; transepidermal water loss; Th; T helper; TSLP; thymic stromal lymphopoiete
Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies
Keywords: Microfluidics; Hepatocytes; Micropatterned Co-Cultures; Spheroids; Bioprinting; Cellular Microarrays; BAL; bioartificial liver; CRP; C-reactive protein; CYP450; cytochrome P450; DILI; drug-induced liver injury; ECM; extracellular matrix; HSC; hepatic stel
Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells
Keywords: 2-DG; 2-deoxyglucose; 3-MST; 3-mercaptopyruvate sulfurtransferase; 5-FU; 5-fluorouracil; AA; antimycin A; ABC; ATP-binding cassette; AMPK; AMP kinase; AOAA; aminooxyacetic acid; ATM; ataxia-telangiectasia mutated serine/threonine protein kinase; ATP; aden
A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells
Keywords: Micropatterned Cocultures; Tricultures; LSECs; HUVECs; 3T3-J2 Fibroblasts; CD31; cluster of differentiation 31; CD54; cluster of differentiation 54; cDNA; complementary DNA; CYP450; cytochrome P-450; ECM; extracellular matrix; F8; factor VIII; GAPDH; glyc
Environmentally relevant concentrations of glibenclamide induce oxidative stress in common carp (Cyprinus carpio)
Keywords: Oxidative damage; Antioxidant enzymes; Hyperglycemic agent; Teleost; CAT; Catalase; CHP; Cumene hydroperoxide; CYP450; Cytochrome P450; EC50; Median effective concentration; GLB; Glibenclamide; HPC; Hydroperoxide content; HPLC-MS/MS; High performance liqu
The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Keywords: Mitochondria; Drug-induced liver injury; HepaRG; Seahorse; Glucose/galactose; Bioenergetic phenotype; ALR; ATP-linked respiration; BCA; bicinchoninic Acid; BR; basal respiration; CCCP; cyanide m-chlorophenyl hydrazine; CPT; carnitine palmitoyl transferase