Silencing strategies for therapy of SOD1-mediated ALS
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Therapy; RNAi; SOD1; ALS;
مقالات ISI RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده (ترجمه نشده)
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Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate cancer tumours
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; RNAi; Cyclodextrin; GALA; siRNA delivery; Prostate cancer; Metastasis; Folate;
Characterization and expression analysis of serpinB3, the first clade B serine protease inhibitor in Pacific white shrimp, Litopenaeus vannamei
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Litopenaeus vannamei; SerpinB3; RNAi; Prophenoloxidase;
Direct experimental manipulation of intestinal cells in Ascaris suum, with minor influences on the global transcriptome
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Nematode; A. suum; RNAi; Intestine; Methodology; dsRNA;
Characterization of heat shock protein 70 transcript from Nilaparvata lugens (Stål): Its response to temperature and insecticide stresses
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Hsp70; Temperature stress; Insecticide; Nilaparvata lugens; RNAi;
Characterization and functional analysis of a carboxylesterase gene associated with chlorpyrifos resistance in Nilaparvata lugens (Stål)
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Insecticide resistance; Carboxylesterase; Chlorpyrifos; RNAi; Nilaparvata lugens;
Evolution of developmental control mechanismsWingless is a positive regulator of eyespot color patterns in Bicyclus anynana butterflies
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Novel trait; Morphogen; Transgenesis; RNAi;
Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Colorectal cancer; PEG-coated shRNA-lipoplex; RNAi; S-1; Short hairpin RNA; Thymidylate synthase;
StPBS2, a MAPK kinase gene, is involved in determining hyphal morphology, cell wall development, hypertonic stress reaction as well as the production of secondary metabolites in Northern Corn Leaf Blight pathogen Setosphaeria turcica
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Setosphaeria turcica; MAPKK; StPBS2; RNAi;
FmLC5, a putative galactose-binding C-type lectin with two QPD motifs from the hemocytes of Fenneropenaeus merguiensis participates in shrimp immune defense
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Fenneropenaeus merguiensis; QPD motif; Dual-CRD lectin; RNAi; In situ hybridization; Innate immunity;
Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Peptide; Homing/targeting; Cell-penetrating; Endosome-disruptive; Oral cancer; OSCC; siRNA; RNAi; EGFR; CIP2A;
Cloning and functional analysis of succinate dehydrogenase gene PsSDHA in Phytophthora sojae
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Phytophthora sojae; Succinate dehydrogenase; RNAi; Phenotypic analysis;
Composite liposome-PEI/nucleic acid lipopolyplexes for safe and efficient gene delivery and gene knockdown
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Linear polyethylenimine; Polyplex; RNAi; Gene therapy; Electron microscopy;
Potential of RNAi applications to control viral diseases of farmed shrimp
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; dsRNA; double-stranded RNA(s); VLP; viral-like particle(s); dsRNA; Penaeid shrimp; Viral infection; White spot syndrome virus; RNAi;
Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; MDR; multidrug resistance; SRB; sulforhodamine B; siRNA; short interfering RNA; RNAi; RNA interference; Mdr1; multidrug resistance protein 1; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; MRP1; multidrug resistance associated protein 1; β
RNAi knock-down of the Bemisia tabaci Toll gene (BtToll) increases mortality after challenge with destruxin A
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Bemisia tabaci; BtToll; Innate immunity; RNAi; Destruxin A;
Molecular and functional characterization of Bm05br antigen from Rhipicephalus microplus
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Bm05br; tick; Rhipicephalus microplus; RNAi; reproduction;
Downregulation of TRB3 protects neurons against apoptosis induced by global cerebral ischemia and reperfusion injury in rats
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; ANOVA; analysis of variance; ATF4; transcription factor 4; Bad; Bcl-2-associated death protein; BCA; bicinchoninic acid assay; CA; cornu ammonis; CHOP; CCAAT/enhancer-binding protein (C/EBP) homologous protein; DAB; diaminobenzidine; DAPI; 4,6,diamidino-2
Liposome-polyethylenimine complexes (DPPC-PEI lipopolyplexes) for therapeutic siRNA delivery in vivo
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Lipopolyplex; Polyethlyenimine; Liposome; siRNA therapy; RNAi; siRNA delivery; Survivin; dH2O; distilled water; DPPC; 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; Luc; luciferase; PEI; polyethylenimine; RNAi; RNA interference; siRNA; small interfering RNA
A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; CRISPR-Cas9; HeLa; Telomere; RNAi;
Involvement of SNARE protein Ykt6 in glycosome biogenesis in Trypanosoma brucei
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; BSF; bloodstream form; ER; endoplasmic reticulum; PCF; procyclic form; RNAi; RNA interference; SNARE; soluble NSF attachment protein receptor; Organelle biogenesis; Trypanosome; Glycosome; SNARE protein; Ykt6; Glycolysis; Peroxisome;
Research articleSuppression of the MADS-box gene SlMBP8 accelerates fruit ripening of tomato (Solanum lycopersicum)
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; MADS-box gene; Fruit ripening; Carotenoid accumulation; Storage; Tomato (Solanum lycopersicum); ACC; 1-aminocyclopropane-1-carboxylic acid; WT; Wild-type; B; breaker; IMG; immature green; MG; mature green; RNAi; RNA interference; RT-PCR; reverse transcrip
The immunomodulatory protein RH36 is relating to blood-feeding success and oviposition in hard ticks
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Immunomodulatory molecules; RH36; RNAi; Oviposition;
Ferritin 1 silencing effect in Rhipicephalus sanguineus sensu lato (Acari: Ixodidae) during experimental infection with Ehrlichia canis
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Rhipicephalus sanguineus s.l; RNAi; Ovaries; Oogenesis; ferritin 1; Ehrlichia canis;
RNA interference for glioblastoma therapy: Innovation ladder from the bench to clinical trials
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; RNAi; Glioblastoma; GBM; Nanoparticles; Mouse models;
Research paper'Nano-in-nano' hybrid liposomes increase target specificity and gene silencing efficiency in breast cancer induced SCID mice
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Liposome; siRNA; Gene delivery; Lipoplexes; RNAi; Poly-l-lysine; EpCAM; Hybrid liposomes;
Enhancement of antiviral capacity of transgenic silkworms against cytoplasmic polyhedrosis virus via knockdown of multiple viral genes
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Antiviral capacity; BmCPV; Resistance; RNAi; Silkworm; Transgenic;
The Role of RNA Interference in Stem Cell Biology: Beyond the Mutant Phenotypes
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; RNAi; RNA interference; siRNA; small interfering RNA; sRNA; small RNA; miRNA; microRNA; mESCs; mouse embryonic stem cells; ICM; inner cell mass; LIF; leukemia inhibitory factor; BMP4; bone morphogenetic factor-4; GSK3; glycogen synthase kinase-3; OSN; OCT
Overexpression and purification of Dicer and accessory proteins for biochemical and structural studies
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; RNAi; Dicer; Loqs-PD; R2D2; Baculovirus; Protein purification;
Molecular characterization and function of the Prohibitin2 gene in Litopenaeus vannamei responses to Vibrio alginolyticus
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Litopenaeus vannamei; PHB2; ROS; p53; RNAi; subcellular localization; luciferase reporter assays;
Modeling of the catalytic core of Arabidopsis thaliana Dicer-like 4 protein and its complex with double-stranded RNA
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; RNAi; siRNA; siRNA biogenesis; Dicer-like proteins; Homology modeling; PAZ; RNase III;
Fyn regulates multipolar-bipolar transition and neurite morphogenesis of migrating neurons in the developing neocortex
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Cdk5; cyclin-dependent kinase 5; CP; cortical plate; EGFP; enhanced green fluorescent protein; FAK; focal adhesion kinase; IZ; intermediate zone; MZ; marginal zone; PB; phosphate buffer; PFA; paraformaldehyde; RNAi; RNA interference; SFKs; Src family kina
TPP-dendrimer nanocarriers for siRNA delivery to the pulmonary epithelium and their dry powder and metered-dose inhaler formulations
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; RNAi; RNA interference; siRNA; short interfering RNA; PAMAM; poly(amidoamine); G4NH2; generation 4 amine-terminated PAMAM dendrimer; TPP; triphenylphosphonium((3carboxypropyl)triphenylphosphonium bromide); pMDIs; pressurized metered dose inhalers; HFAs; h
An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; RNAi; Knockdown; shRNA; miR-30; Lentiviral vector; Tet-regulation;
Research PaperA rapid chemical-genetic screen utilizing impaired movement phenotypes in C. elegans: Input into genetics of neurodevelopmental disorders
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; ASD; autism spectrum disorder; NDD; neurodevelopmental disorders; ADHD; attention deficit hyperactivity disorders; WT; wildtype; SNPs; single nucleotide polymorphism; SFARI; Simons Foundation Autism Research Initiative; GABA; γ-aminobutyric acid; RNAi; R
ETS transcription factor ELF5 induces lumen formation in a 3D model of mammary morphogenesis and its expression is inhibited by Jak2 inhibitor TG101348
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; CEACAM1; ELF5; JAK2; Breast cancer; Mammary morphogenesis; RNAi;
Knockdown of nuclease activity in the gut enhances RNAi efficiency in the Colorado potato beetle, Leptinotarsa decemlineata, but not in the desert locust, Schistocerca gregaria
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; RNA interference; RNAi; Colorado potato beetle; Desert locust; dsRNase; Nuclease; dsRNA;
Molecular cloning, characterization and function of a germinal center kinase MST4 gene from Litopenaeus vannamei in response to Vibrio alginolyticus challenge in TLR-TRAF6 signaling pathway
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; LvMST4; Vibrio alginolyticus challenge; TLR-TRAF6 signal pathway; Immunologic homeostasis; RNAi;
Knocking down chitin synthase 2 by RNAi is lethal to the cotton boll weevil
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Peritrophic membrane; Midgut; Insect pest control; RNAi;
Identification and characterization of a Masculinizer (Masc) gene involved in sex differentiation in Artemia
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Masc; Masculinizer; AG; androgenic gland; IAG; insulin-like AG-specific factors; Dsx; Doublesex; Bmdsx; Doublesex orthologue of B. mori; piRNA; PIWI-interacting RNAs; EO; early oocyte stage; LO; late oocyte stage; Ar-Masc; Artemia Masculinizer gene; ORF;
Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BCA; bicinchoninic acid; CA; Cornu Ammonis; DG; Dentate Gyrus; DIV; days in vitro; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GFAP; Glial Fibrilary Acidic Protein; GFP; Green Fluorescent P
Silencing of BnTT1 family genes affects seed flavonoid biosynthesis and alters seed fatty acid composition in Brassica napus
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; TT1; TRANSPARENT TESTA1; RNAi; RNA interference; PA; proanthocyanidin; PC; procyanidin oligomer; DP; degree of polymerization of the epicatechin unit; tt; transparent testa; WT; wild type; TT1-RNAi & R; RNAi transgenic plants harboring pFGC5941M-BTT1I; DA
Full length articleEvolutionary developmental biology (evo-devo) of cestodes
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Neodermata; Oncosphere; Metacestode; Echinococcus; Hymenolepis; Planarian; AP; antero-posterior; DAPI; 4â²,6-diamidino-2-phenylindole; RNAi; RNA interference; RPKM; reads per kilobase per million reads; WMISH; whole-mount in situ hybridization;
Neural organoids for disease phenotyping, drug screening and developmental biology studies
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Human induced pluripotent stem cells; Embryonic stem cells; Cerebral organoids; Disease modeling; Drug screening; hiPSCs; Human induced pluripotent stem cells; CNS; central nervous system; 2D; two-dimensional; 3D; three-dimensional; ESCs; embryonic stem c
VAMP4 and its cognate SNAREs are required for maintaining the ribbon structure of the Golgi apparatus
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; siRNA; small interfering RNA; ER; endoplasmic reticulum; SNAREs; soluble N ethylmaleimide sensitive factor adaptor protein receptor; VAMP4; vesicle-associated membrane protein 4; TGN; trans-Golgi network; EE; early endosome; RNAi; RNA interference; FRAP;
Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; AGE; advanced glycation end-product; AU; arbitrary units; C. elegans; Caenorhabditis elegans; ctrl; control; DAF; abnormal dauer formation; DN; diabetic neuropathy; E. coli; Escherichia coli; FCCP; carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; FOX
In vitro stimulation of vitellogenin expression by insulin in the mud crab, Scylla paramamosain, mediated through PI3K/Akt/TOR pathway
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Insulin-like peptide; Vitellogenin; In vitro experiments; RNAi; Scylla paramamosain;
Targeted si-RNA with liposomes and exosomes (extracellular vesicles): How to unlock the potential
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Lipid nanoparticles; Exosomes; Extracellular vesicles; targeted delivery; RNAi; siRNA; Cationic lipid;
Structural Foundations of RNA Silencing by Argonaute
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; Argonaute; RNA-induced silencing complex; RNA silencing; microRNA; RISC; RNA-induced silencing complex; miRNAs; microRNAs; siRNAs; small interfering RNAs; RNAi; RNA interference; piRNAs; Piwi-interacting RNAs; RLC; RISC-loading complex; RNase H; ribonucle
siRNA-nanoparticle conjugate in gene silencing: A future cure to deadly diseases?
Keywords: RNA سرکوبگر،RNA مداخله‌گر، RNA خاموش کننده; siRNA-nanoparticle conjugates; Gene silencing; Biocompatibility; Cancer; RNAi; Alzheimer's disease;