Keywords: CRAT; carnitine acetyltransferase; LC-MS; Liquid Chromatography Mass Spectrometry; PDH; Pyruvate Dehydrogenase; T2DM; type 2 diabetes mellitus; ZDF; Zucker diabetic fatty; Carnitine acetyltransferase; Type 2 diabetes mellitus; Insulin; Resistance; Acylcar
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Keywords: ADA; anti-drug antibody; ALN; alendronate; AUC; area under curve; BFR/BS; bone formation rate per bone surface; BMD; bone mineral density; bSEM; backscattered scanning electron microscopy; CKD-MBD; chronic kidney disease-mineral and bone disorder; CTX; ca
Keywords: SGLT2 inhibitor; DPP4 inhibitor; Canagliflozin; Combination treatment; Glucagon-like peptide-1; aGLP-1; active GLP-1; ANOVA; Analysis of variance; AUC; Area under the curve; CMA; (2S)-2-Cyano-1-[trans-4-(morpholinocarbonyl)cyclohexylamino]acetylpyrrolidin
Keywords: 2,5-HD; 2,5-hexanedione; LC; lean control; NO; nitric oxide; NADPHd; NADPH diaphorase; nNOS; neuronal nitric oxide synthase; ZDF; Zucker Diabetic Fatty; Nitric oxide synthase; Dorsal medulla; Diabetic neuropathy; Sensory functions; 2,5-HD intoxication; Im
Keywords: AUC; area under curve; CAT; catalase; DCFH; dichlorofluorescein; DNPH; dinitrophenylhydrazine; GSH; glutathione; GPx; glutathione peroxidase; GR; glutathione reductase; GST; glutathione-S-transferase; GTT; glucose tolerance test; HO-1; heme oxygenase; HOM
Keywords: BB/Wor; BioBreeding/Worcester; BB/Wor-DP; BB/Wor diabetic prone; BB/Wor-DR; BB/Wor diabetic resistant; DPN; diabetic polyneuropathy; STZ; streptozotocin; T1D; type 1 diabetes; T2D; type 2 diabetes; WDR; wide dynamic range; ZDF; Zucker diabetic fatty; ZL;
Keywords: HHcy; hyperhomocysteinemia; ZDF; Zucker diabetic fatty; CβS; cystathionine β-synthase; BHMT; betaine-homocysteine methyltransferase; SAM; S-adenosylmethionine; SAH; S-adenosylhomocysteine; MS; methionine synthase; GSH; glutathione; CDO; cysteine dioxyge
Keywords: ACAT2; acyl-CoA: cholesterol acyltransferase; ASVD; atherosclerotic vascular disease; COPs; cholesterol oxidation products; HDL; high density lipoprotein; HUVECs; umbilical venous endothelial cells; ICAM; intercellular adhesion molecule; IL; interleukin;
CREB1 functional polymorphisms modulating promoter transcriptional activity are associated with type 2 diabetes mellitus risk in Chinese population
Keywords: CREB1; cAMP responsive element binding protein 1; T2D; type 2 diabetes mellitus; ZDF; Zucker diabetic fatty; STZ; streptozotocin; SNP; single nucleotide polymorphism; GWAS; genome-wide association study; OGTT; oral glucose tolerance test; aCRS-RFLP; ampli
A TSPO ligand prevents mitochondrial sterol accumulation and dysfunction during myocardial ischemia-reperfusion in hypercholesterolemic rats
Keywords: TSPO; translocator protein; ZDF; Zucker diabetic fatty; mPTP; mitochondrial permeability transition pore; Cardiac mitochondria; Sterol; Hypercholesterolemia; Ischemia-reperfusion injury; Translocator protein;
Modulation of signaling mechanisms in the heart by thioredoxin 1
Keywords: Akt; protein kinase B; AMPK; Adenosine Monophosphate-activated Protein Kinase; Ang-II; Angiotensin-II; AP1; Activator protein 1 (AP-1); ASK1; Apoptosis Signal-regulating kinase; Atg4; Autophagy related-4; ATP; Adenosine Triphosphate; CDDP; cis-diammine-di
The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
Keywords: ACh; acetylcholine; AGE; advanced glycation end products; ALDH-2; mitochondrial aldehyde dehydrogenase; CCL-2; see MCP-1; ChIP; chromatin immunoprecipitation; COX2; cyclooxygenase-2; CRP; C-reactive protein; DHE; dihydroethidine; DHFR; dihydrofolate reduc
Stratified analysis of lectin-like chaperones in the folding disease-related metabolic syndrome rat model
Keywords: Endoplasmic reticulum; Chaperone; Diabetes mellitus; Obesity; Protein interaction; Aggregation; CRT; calreticulin; CNX; calnexin; d-OVA; denatured ovalbumin; ER; endoplasmic reticulum; MDH; malate dehydrogenase; OVA; ovalbumin; TBS; Tris-buffered saline;
The SGLT2 inhibitor empagliflozin improves insulin sensitivity in db/db mice both as monotherapy and in combination with linagliptin
Keywords: DIO; diet-induced obese; DPP; dipeptidyl peptidase; FAS; fatty acid synthase; FPG; fasting plasma glucose; GDR; glucose disposal rate; HbA1c; glycated hemoglobin; HGP; hepatic glucose production; HPRT; hypoxanthine phosphoribosyltransferase; OGTT; oral gl
Roux-en-Y gastric bypass attenuates the progression of cardiometabolic complications in obese diabetic rats via alteration in gastrointestinal hormones
Keywords: RYGB; Diabetes; Cardiovascular; ZDF; GI hormones;
Cocoa and cocoa flavanol epicatechin improve hepatic lipid metabolism in in vivo and in vitro models. Role of PKCζ
Keywords: AKT; protein kinase B; AMPK; AMP-activated protein kinase; aPKC; atypical protein kinase C; Cho; cholesterol; EC; (â)-epicatechin; EDTA; ethylenediaminetetraacetic acid; NEFA; non-esterified fatty acids; PFA; paraformaldehyde; PKC; protein kinase C; PMS
Effect of linagliptin, alone and in combination with voglibose or exendin-4, on glucose control in male ZDF rats
Keywords: GLP-1; glucagon-like peptide 1; DPP-4; dipeptidyl peptidase-4; ZDF; Zucker diabetic fatty; B1; baseline blood-sampling time-point before drug treatment; B2; baseline blood-sampling time-point 60Â min after treatment but before the sucrose or glucose load;
Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins
Keywords: CHO; Chinese hamster ovary cells; CHOIR; Chinese hamster ovary (CHO) cells stably transfected with the human wild-type insulin receptor; ERK; extracellular signal-regulated kinases 1 and 2; GS; glycogen synthase; GSK3β; glycogen synthase kinase-3β; IR;
Long-term liraglutide treatment is associated with increased insulin content and secretion in β-cells, and a loss of α-cells in ZDF rats
Keywords: ANOVA; analysis of variance; BSA; bovine serum albumin; EM; electron microscope; ER; endoplasmic reticulum; GLP-1; glucagon-like peptide-1; HbA1c; glycated hemoglobin; HRP; horseradish peroxidase; IACUCI; nstitutional Animal Care and Use Committee; IF; im
Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes
Keywords: Adipo-IR; adipose insulin resistance; HOMA-IR; the homeostasis model assessment of insulin resistance; NEFA; non-esterified fatty acids; OGTT; oral glucose tolerance tests; RCR; Rhodiola crenulata root; ZDF; Zucker diabetic fatty; ZL; Zucker lean; Rhodiol
Adiponectin negatively correlated with carotid arterial structure in the leptin-resistant Zucker diabetic fatty rat
Keywords: Leptin; Adiponectin; Luminal cross-sectional area; Medial cross-sectional area; Wall stress; Zucker diabetic fatty rats; BP; blood pressure; Di; mean internal diameter; EP; external perimeter; h; medial thickness; IMT; intima-media thickness; IP; internal
Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model
Keywords: GP, glycogen phosphorylase; G6P, glucose-6-phosphate; PC, pyruvate carboxylase; PDH, pyruvate dehydrogenase; SprD, Sprague–Dawley; ZDF, Zucker Diabetic FattyBrain metabolism; 13C-glucose; Glycogen phosphorylase; CP-316,819; SprD; ZDF
Skeletal muscle lipid metabolism studied by advanced magnetic resonance spectroscopy
Keywords: ATP; adenosine tri-phosphate; BMI; body mass index; BMS; bulk magnetic susceptibility; CABINET; coherence transfer spin-echo spectroscopy; CHESS; chemical shift selective; CSI; chemical shift imaging; DM; diabetes mellitus; DTI; diffusion tensor imaging;
Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes
Keywords: Insulin secretion; Glycerolipid/fatty acid cycle; Glucolipotoxicity; Lipogenesis; Lipolysis; ABHD6; α/β-domain containing hydrolase-6; ADRP; adipocyte differentiation-related protein; AGPAT; 1-acyl-sn-glycerol-3-phosphate acyltransferase; AMPK; AMP acti
Punica granatum flower extract, a potent α-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats
Keywords: FPG; fasting plasma glucose; PG; Punica granatum; PGF; Punica granatum flowers; ZL; Zucker lean; ZDF; Zucker diabetic fatty; CVD; cardiovascular disease; Punica granatum; Postprandial hyperglycemia; α-Glucosidase; Diabetes; Zucker diabetic fatty rats;
Fatty acid metabolism is enhanced in type 2 diabetic hearts
Keywords: FA; free (non-esterified) fatty acid(s); TG; triacylglycerol(s); ZDF; Zucker diabetic fatty rat; CM; chylomicrons; VLDL; very-low-density lipoproteins; LPL; lipoprotein lipase; FAT/CD36; fatty acid translocase/CD36; FABPpm; plasma membrane fatty acid bind