کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2845150 1166380 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acoustic startle and prepulse inhibition in the Mongolian gerbil
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Acoustic startle and prepulse inhibition in the Mongolian gerbil
چکیده انگلیسی

The acoustic startle response has been studied in great detail in rodents, however almost only in rats and mice, two very similar, domesticated animals. The Mongolian gerbil (Meriones unguiculatus) is an established animal model for auditory research with good low-frequency hearing that covers most of the human audiogram. Gerbils have also been used to investigate the influence of domestication on auditory-related behavior. We characterized the acoustic startle response in gerbils and determined the influence of domestication by directly comparing animals from a domesticated with a wild-type strain. Mongolian gerbils showed a strong and reliable acoustic startle response to noise bursts above a threshold of 77–80 dB SPL which levels out above 115 dB SPL. Only domesticated gerbils showed short-term habituation to repetitive stimulation while the responses in wild-type animals remained at about the same level. Prepulse inhibition of the acoustic startle response by noise burst or gap-in-noise prepulses in gerbils was strong, maximum prepulse inhibition induced by noise bursts was between 67% (wild-types) and 90% (domesticated). Differences between domesticated and wild-type gerbils were even more pronounced for gap-prepulse inhibition. For a gap duration of 50 ms with a lead time of 100 ms, percent inhibition in domesticated gerbils (80%) was almost double the inhibition in wild-types. Such strong prepulse inhibition can be very useful as a basis for efficient audiometric measurements in gerbils.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 98, Issue 4, 19 October 2009, Pages 460–466
نویسندگان
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