کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3356354 1217257 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The proteasome function is required for Mycobacterium leprae-induced apoptosis and cytokine secretion
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The proteasome function is required for Mycobacterium leprae-induced apoptosis and cytokine secretion
چکیده انگلیسی

Previous studies have demonstrated the importance of the ubiquitin–proteasome pathway in the immune response to bacterial pathogens. To investigate the role of this system in the context of leprosy, Mycobacterium leprae-stimulated peripheral blood mononuclear cells (PBMC) were treated with the proteasome inhibitor MG132 to assess the levels of apoptosis and cytokine secretion. The results showed that the inhibition of proteasome activity significantly reduced M. leprae-mediated cell death. In addition, MG132 treatment led to a significant decrease in M. leprae-induced TNF-α and IL-10 secretion. Together, these results suggest that modulations of the ubiquitin–proteasome pathway may participate in the human response to M. leprae.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 110, Issue 1, 15 May 2007, Pages 82–85
نویسندگان
, , , , ,