کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3368367 1218785 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extrathymic mechanisms of T cell tolerance: Lessons from autoimmune gastritis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Extrathymic mechanisms of T cell tolerance: Lessons from autoimmune gastritis
چکیده انگلیسی

While the thymus plays a key role in the prevention of many autoimmune phenomena it is clear that robust mechanisms external to the thymus are also vital in controlling self-reactive T cells. Here we review the current concepts in the field of extrathymic tolerance and use recent studies of autoimmune gastritis to illustrate how T cells directed to a prominent, clinically relevant autoantigen, namely the gastric proton pump, can be silenced with little or no thymic involvement. Autoimmune gastritis represents one of the most thoroughly characterised autoimmune systems and the knowledge and tools available to study this disease will continue to allow a thorough assessment of the genetic, cellular and molecular events that underlie tolerance and autoimmunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 31, Issue 3, November 2008, Pages 268–273
نویسندگان
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