کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4370972 1617004 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of in vitro inhibitory effect of enoxacin on Babesia and Theileria parasites
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Evaluation of in vitro inhibitory effect of enoxacin on Babesia and Theileria parasites
چکیده انگلیسی


• Enoxacin is a broad-spectrum antibacterial agent.
• Enoxacin potently inhibited the Babesia and Theileria parasites.
• Enoxacin might be used as a treatment for Babesia and Theileria parasites.

Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid used mainly in the treatment of urinary tract infections and gonorrhea. Also it has been shown recently that it may have cancer inhibiting effect. The primary antibabesial effect of Enoxacin is due to inhibition of DNA gyrase subunit A, and DNA topoisomerase. In the present study, enoxacin was tested as a potent inhibitor against the in vitro growth of bovine and equine Piroplasms. The in vitro growth of five Babesia species that were tested was significantly inhibited (P < 0.05) by micro molar concentrations of enoxacin (IC50 values = 33.5, 15.2, 7.5 and 23.2 μM for Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi, respectively). Enoxacin IC50 values for Babesia and Theileria parasites were satisfactory as the drug is potent antibacterial drug with minimum side effects. Therefore, enoxacin might be used for treatment of Babesiosis and Theileriosis especially in case of mixed infections with bacterial diseases or incase of animal sensitivity against diminazin toxicity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 161, February 2016, Pages 62–67
نویسندگان
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