کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5225693 | 1383555 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Syntheses of fluorine-containing mucin core 2/core 6 structures using novel fluorinated glucosaminyl donors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Syntheses of fluorine-containing mucin core 2/core 6 structures using novel fluorinated glucosaminyl donors Syntheses of fluorine-containing mucin core 2/core 6 structures using novel fluorinated glucosaminyl donors](/preview/png/5225693.png)
چکیده انگلیسی
Syntheses of fluorinated mucin core 6 disaccharides and core 2 trisaccharides modified at the C-3 or C-4 position of the pertinent glucosamine residue required for mechanistic study of glycosyltransferases and sulfotransferases involved in the biosynthesis of O-glycans are reported. Novel fluorinated glucosaminyl donors were synthesized from 2-naphthylmethyl β-d-N-acetylglucosamine (β-O-NAP-GlcNAc) via double inversion of the C-3 or C-4 configuration. A one-step β-alkylation of GlcNAc was reported for the first time to afford β-O-NAP-GlcNAc in high yield, which constitutes the cornerstone of the synthetic strategy based on NAP-glycosides in oligosaccharides synthesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 40, 3 October 2009, Pages 8325-8335
Journal: Tetrahedron - Volume 65, Issue 40, 3 October 2009, Pages 8325-8335
نویسندگان
Jun Xue, Vipin Kumar, Sirajud D. Khaja, E.V. Chandrasekaran, Robert D. Locke, Khushi L. Matta,