Leptin Replacement Restores Supraspinal Cholinergic Antinociception in Leptin-Deficient Obese Mice

This study specifies a brain region (the pontine reticular formation), cholinergic neurotransmission, and a protein (leptin) modulating thermal nociception. The results are relevant for efforts to understand the association between obesity, disordered sleep, and hyperalgesia.